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<p>Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (<b>1</b>) and B (<b>2</b>), and a new phthalide monomer (<b>3</b>), were obtained from the rhizomes of <i>Angelica sinensis</i>. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds <b>1</b> and <b>2</b> were [2 + 2] and [4 + 2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds <b>2</b>, (+)-<b>2</b>, (−)-<b>2</b>, <b>4</b>, (+)-<b>4</b>, and (−)-<b>4</b> exhibited significant inhibitory activity against NO production with IC<sub>50</sub> values range from 1.23 to 5.55&#xa0;μM.</p> Graphical Abstract <p></p>

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Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月24日

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  • Hongyan Wen,
  • Sheng Li,
  • Yu Zhang

摘要

Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide monomer (3), were obtained from the rhizomes of Angelica sinensis. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds 1 and 2 were [2 + 2] and [4 + 2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds 2, (+)-2, (−)-2, 4, (+)-4, and (−)-4 exhibited significant inhibitory activity against NO production with IC50 values range from 1.23 to 5.55 μM.

Graphical Abstract