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<p>A series of structurally diverse polyketides (<b>1–3</b>), sesterterpenoids (<b>24</b> and <b>25</b>), and alkaloids (<b>26–34</b>) were isolated from the fermentation of a plant-derived fungus <i>Penicillium canescens</i> L1 on solid rice medium. Among these secondary metabolites, penicanesols A<b>–</b>G (<b>1–7</b>) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (<b>1</b>) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound <b>13</b> had an IC<sub>50</sub> value of 4.24 ± 0.13&#xa0;μM, more than the positive control drug (12.99 ± 0.13&#xa0;μM).</p> Graphical Abstract <p></p>

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Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月3日

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  • Wei-Ye Wu,
  • Xun Wei,
  • Qiong Liao,
  • Yi-Fan Fu,
  • Lei-Ming Wu,
  • Lei Li,
  • Shu-Qi Wu,
  • Qing-Ren Lu,
  • Fang-Yu Yuan,
  • Dong Huang,
  • Zhang-Hua Sun,
  • Tao Yuan,
  • Gui-Hua Tang

摘要

A series of structurally diverse polyketides (1–3), sesterterpenoids (24 and 25), and alkaloids (26–34) were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium. Among these secondary metabolites, penicanesols A–G (1–7) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (1) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound 13 had an IC50 value of 4.24 ± 0.13 μM, more than the positive control drug (12.99 ± 0.13 μM).

Graphical Abstract