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<p>Teucrifarides A–D (<b>1</b>–<b>4</b>), four previously unreported <i>neo</i>-clerodane-type diterpenoids, combined with sixteen known analogs (5–20), were purified from <i>Teucrium quadrifarium.</i> The absolute forma of compounds <b>1</b>–<b>4</b> were determined via spectroscopic and ECD calculation methods, together with X-ray crystallography experiments. Among them, compound <b>1</b> possessed a 5,20-epoxy ring featuring a unique cage-like 12-oxatricyclo [5.3.2.0<sup>1,6</sup>]undecane skeleton. Meanwhile, 2 incorporated a 6,20-epoxy ring with a novel 12-oxatricyclo [6.2.2.0<sup>2,7</sup>]undecane skeleton. Compounds <b>1</b> and <b>12</b> exhibited significant inhibitory effects against HT-22 cells ferroptosis induced by RSL3, with EC<sub>50</sub> values of 11.8 ± 1.0&#xa0;μM, and 4.52 ± 1.24&#xa0;μM, respectively. Moreover, ROS accumulation in HT22 cells treated with compound <b>1</b> was also observed.</p> Graphical Abstract <p></p>

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Novel neo-clerodane diterpenoids from Teucrium quadrifarium and their anti-ferroptosis effect

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月6日

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  • Huan Wang,
  • Han-Fei Liu,
  • Xiao-Qiao Yang,
  • Yu-Qiong Liao,
  • Fen-Cong Pan,
  • Jin-Yu Li,
  • Hua-Yong Lou,
  • Wei-Dong Pan

摘要

Teucrifarides A–D (1–4), four previously unreported neo-clerodane-type diterpenoids, combined with sixteen known analogs (5–20), were purified from Teucrium quadrifarium. The absolute forma of compounds 1–4 were determined via spectroscopic and ECD calculation methods, together with X-ray crystallography experiments. Among them, compound 1 possessed a 5,20-epoxy ring featuring a unique cage-like 12-oxatricyclo [5.3.2.01,6]undecane skeleton. Meanwhile, 2 incorporated a 6,20-epoxy ring with a novel 12-oxatricyclo [6.2.2.02,7]undecane skeleton. Compounds 1 and 12 exhibited significant inhibitory effects against HT-22 cells ferroptosis induced by RSL3, with EC50 values of 11.8 ± 1.0 μM, and 4.52 ± 1.24 μM, respectively. Moreover, ROS accumulation in HT22 cells treated with compound 1 was also observed.

Graphical Abstract