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<p>Radical cystectomy (RC) is traditionally considered the standard treatment for non-metastatic muscle-invasive bladder cancer (MIBC), although randomized evidence of superiority over bladder-preserving therapy (BPT) is lacking. In this nationwide study, we included all patients diagnosed with non-metastatic MIBC between 2017 and 2019 and treated with curative-intent with either RC or BPT. A&#xa0;total of 1,432 patients were included (1,101 RC, 331 BPT). The primary endpoint was 2‑year disease-free survival (DFS), with overall survival (OS) as the secondary endpoint. IPTW-adjusted 2‑year DFS was 61.5% for BPT and 55.3% for RC (HR 0.84; 95%-CI 0.69–1.05). Two-year OS was 74.0% for BPT versus 66.0% for RC (HR 0.80; 95%-CI 0.64–0.98). DFS was comparable between groups, while OS favored BPT.</p>

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Spierinvasieve blaaskanker in Nederland: oncologische uitkomsten na radicale cystectomie en blaassparende therapie

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月2日

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  • Katharina Brück,
  • Richard P. Meijer,
  • Joost L. Boormans,
  • Lambertus A. Kiemeney,
  • J. Alfred Witjes,
  • Lisa M. C. van Hoogstraten,
  • Michiel S. van der Heijden,
  • A. Rogier Donders,
  • Martine Franckena,
  • Carin A. Uyl-de Groot,
  • Annemarie M. Leliveld-Kors,
  • Katja K. H. Aben,
  • Maarten C. C. M. Hulshof

摘要

Radical cystectomy (RC) is traditionally considered the standard treatment for non-metastatic muscle-invasive bladder cancer (MIBC), although randomized evidence of superiority over bladder-preserving therapy (BPT) is lacking. In this nationwide study, we included all patients diagnosed with non-metastatic MIBC between 2017 and 2019 and treated with curative-intent with either RC or BPT. A total of 1,432 patients were included (1,101 RC, 331 BPT). The primary endpoint was 2‑year disease-free survival (DFS), with overall survival (OS) as the secondary endpoint. IPTW-adjusted 2‑year DFS was 61.5% for BPT and 55.3% for RC (HR 0.84; 95%-CI 0.69–1.05). Two-year OS was 74.0% for BPT versus 66.0% for RC (HR 0.80; 95%-CI 0.64–0.98). DFS was comparable between groups, while OS favored BPT.