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<p>The prognosis of patients with muscle-invasive bladder cancer (MIBC) has hardly improved over the past thirty years. In the Netherlands, approximately 2,200 patients are diagnosed with MIBC each year. Despite curative-intent local treatment, about half of these patients die within five years after diagnosis. This suggests that, in a&#xa0;subset of patients, the disease is already metastatic at the time of initial treatment. A&#xa0;possible explanation is that the current standard method for local staging –&#xa0;the complete removal of the tumour in the operating room through transurethral resection (TURBT)&#xa0;– may contribute to tumour cell dissemination. A&#xa0;randomized two-arm study is currently ongoing in the Netherlands to evaluate whether bladder MRI combined with outpatient biopsy provides a&#xa0;safer, more cost-effective, and faster alternative for detecting muscle invasion in bladder cancer compared to conventional TURBT. In addition, the study investigates whether this approach can shorten the time to definitive treatment. If successful, this could represent a&#xa0;major step forward in the diagnosis and management of bladder cancer.</p>

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Sneller, veiliger, slimmer: mpMRI voor stadiëring van spierinvasieve blaaskanker?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月23日

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  • Sebastiaan W. van Koeverden,
  • Lisa M. C. van Hoogstraten,
  • Lambert A. L. M. Kiemeney,
  • Antoine G. van der Heijden

摘要

The prognosis of patients with muscle-invasive bladder cancer (MIBC) has hardly improved over the past thirty years. In the Netherlands, approximately 2,200 patients are diagnosed with MIBC each year. Despite curative-intent local treatment, about half of these patients die within five years after diagnosis. This suggests that, in a subset of patients, the disease is already metastatic at the time of initial treatment. A possible explanation is that the current standard method for local staging – the complete removal of the tumour in the operating room through transurethral resection (TURBT) – may contribute to tumour cell dissemination. A randomized two-arm study is currently ongoing in the Netherlands to evaluate whether bladder MRI combined with outpatient biopsy provides a safer, more cost-effective, and faster alternative for detecting muscle invasion in bladder cancer compared to conventional TURBT. In addition, the study investigates whether this approach can shorten the time to definitive treatment. If successful, this could represent a major step forward in the diagnosis and management of bladder cancer.