<p>Proniosomes are dry, surfactant-coated carrier particles that readily transform into niosomes upon hydration, forming stable vesicular dispersions capable of encapsulating both hydrophilic and lipophilic drugs. Their physicochemical characteristics, including vesicle size, entrapment efficiency, and release profile, are largely influenced by the choice of carrier and the method of preparation. Compared to other vesicular systems, proniosomes exhibit superior physical stability during storage and transport, prolonged systemic drug retention, enhanced tissue penetration, and reduced toxicity. Importantly, they also address limitations commonly associated with liposomes, such as high production costs and issues related to phospholipid purity. Several formulation strategies have been developed such as the coacervation phase separation method, slurry method, and spray-coating techniques for non-ionic surfactants onto water-soluble carriers each contributing to improved vesicle uniformity and performance. This review highlights recent advancements in the preparation, characterization, and therapeutic applications of proniosomal formulations. Owing to their ability to facilitate efficient drug delivery through multiple administration routes including oral, parenteral, transdermal, ocular, pulmonary, vaginal, and mucosal pathways, proniosomes represent a promising platform for targeted and effective pharmaceutical delivery that warrants continued exploration.</p> Graphical abstract <p></p>