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<p>The global rise of drug-resistant superbugs, particularly <i>Methicillin-resistant Staphylococcus aureus</i> (MRSA), demands the advancement of alternate therapeutic agents. <i>Coriandrum sativum</i> or Coriander (Cor), a medicinal herb with diverse phytochemical properties, has been investigated for its antimicrobial applications. This study carried out the synthesis of Coriander silver nanoparticles (Cor-AgNPs) through Cor-extract obtained from hydroponically grown coriander, ultimately, aimed at combating MRSA-induced skin and soft tissue infections (SSTI). Coriander was grown hydroponically to optimize plant biomass and phytoconstituent’s production. Phytochemical tests including flavonoids, phenols, alkaloids, and terpenoids were carried out. Silver nanoparticles were green-synthesized and characterized for their size, structure, and stability. The antimicrobial potential of these Cor-AgNPs was assessed through in vitro methods, including disc diffusion and turbidometry analysis representing significant inhibition of MRSA growth with a minimum inhibitory concentration (MIC) of 250 µg/ml and minimum bactericidal concentration (MBC) of 1,750 µg/ml. Furthermore, the Cor-AgNPs formulation, integrated into a polyvinyl pyrrolidone-ethylene cellulose (PVP-EC) hydrogel, was evaluated in an in vivo BALB/c mice burn model, where it significantly diminished infection and supported wound healing. This study highlights the potential of <i>C. sativum</i>-derived AgNPs as a promising alternative in the treatment of MRSA infections.</p>

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Phyto-synthesis and pharmacological evaluation of AgNPs using hydroponic coriander for MRSA infected wounds

  • 期刊论文

  • 发表日期：

    2026年5月20日

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  • Syed Damin Abbas Hamdani,
  • Hunaiza Fatima,
  • Mahnoor Ilyas,
  • Alvina Gul,
  • Faiq Musharaf Sabih,
  • Mustafeez Mujtaba Babar

摘要

The global rise of drug-resistant superbugs, particularly Methicillin-resistant Staphylococcus aureus (MRSA), demands the advancement of alternate therapeutic agents. Coriandrum sativum or Coriander (Cor), a medicinal herb with diverse phytochemical properties, has been investigated for its antimicrobial applications. This study carried out the synthesis of Coriander silver nanoparticles (Cor-AgNPs) through Cor-extract obtained from hydroponically grown coriander, ultimately, aimed at combating MRSA-induced skin and soft tissue infections (SSTI). Coriander was grown hydroponically to optimize plant biomass and phytoconstituent’s production. Phytochemical tests including flavonoids, phenols, alkaloids, and terpenoids were carried out. Silver nanoparticles were green-synthesized and characterized for their size, structure, and stability. The antimicrobial potential of these Cor-AgNPs was assessed through in vitro methods, including disc diffusion and turbidometry analysis representing significant inhibition of MRSA growth with a minimum inhibitory concentration (MIC) of 250 µg/ml and minimum bactericidal concentration (MBC) of 1,750 µg/ml. Furthermore, the Cor-AgNPs formulation, integrated into a polyvinyl pyrrolidone-ethylene cellulose (PVP-EC) hydrogel, was evaluated in an in vivo BALB/c mice burn model, where it significantly diminished infection and supported wound healing. This study highlights the potential of C. sativum-derived AgNPs as a promising alternative in the treatment of MRSA infections.