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<p>The loss of cognitive abilities, such as reasoning, memory, and thinking, is known as dementia. The therapeutic value of medicinal plants often arises from their antioxidants. <i>Eleusine indica’s</i> antioxidant activity in the extract is attributed to its phenolic components and abundant secondary metabolites. This study aims to discover the influence of <i>Eleusine indica</i> extract at 100 and 200&#xa0;mg/kg on cognitive enhancement in scopolamine induced memory impairment in Wistar rats. Hydroethanolic extract of <i>Eleusine indica</i> was made using cold maceration followed by Soxhlet instrument, and phytochemical tests were analyzed. Dementia was induced by administration of scopolamine at the dose of 3&#xa0;mg/kg. The efficacy of the extract 100 and 200&#xa0;mg/kg, p.o and the standard drug piracetam 400&#xa0;mg/ kg p.o. in enhancing information recall in animals was assessed through a range of experimental models, including the elevated plus maze, Morris Water Maze, and light-dark model. Biomarkers such as acetylcholinesterase and dopamine in the brain were measured along with various oxidative stress markers. Histopathology of the brain cortex and hippocampus were studied. Treatment with <i>Eleusine indica</i> extract at 200&#xa0;mg/kg significantly reversed the pathogenesis induced by scopolamine, leading to an increase in acetylcholinesterase and dopamine levels. It is evident that decreases in transfer latency in elevated plus maze and Step through latency in Morris Water Maze. <i>Eleusine indica</i> extract showed strong antioxidant potency. Phytoconstituents in extract possesses free radical scavenging ability and protecting the brain structure and functions.</p>

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Exploring the cognitive benefits of Eleusine Indica (L.) Gaertn in alleviating scopolamine-induced dementia in wistar rats

  • 期刊论文

  • 发表日期：

    2025年2月20日

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  • Neelakanth M. Jeedi,
  • Reenal R. Naik,
  • Shrishail K. Nimbal,
  • Santosh B. Patil

摘要

The loss of cognitive abilities, such as reasoning, memory, and thinking, is known as dementia. The therapeutic value of medicinal plants often arises from their antioxidants. Eleusine indica’s antioxidant activity in the extract is attributed to its phenolic components and abundant secondary metabolites. This study aims to discover the influence of Eleusine indica extract at 100 and 200 mg/kg on cognitive enhancement in scopolamine induced memory impairment in Wistar rats. Hydroethanolic extract of Eleusine indica was made using cold maceration followed by Soxhlet instrument, and phytochemical tests were analyzed. Dementia was induced by administration of scopolamine at the dose of 3 mg/kg. The efficacy of the extract 100 and 200 mg/kg, p.o and the standard drug piracetam 400 mg/ kg p.o. in enhancing information recall in animals was assessed through a range of experimental models, including the elevated plus maze, Morris Water Maze, and light-dark model. Biomarkers such as acetylcholinesterase and dopamine in the brain were measured along with various oxidative stress markers. Histopathology of the brain cortex and hippocampus were studied. Treatment with Eleusine indica extract at 200 mg/kg significantly reversed the pathogenesis induced by scopolamine, leading to an increase in acetylcholinesterase and dopamine levels. It is evident that decreases in transfer latency in elevated plus maze and Step through latency in Morris Water Maze. Eleusine indica extract showed strong antioxidant potency. Phytoconstituents in extract possesses free radical scavenging ability and protecting the brain structure and functions.