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<p>Coriander (<i>Coriandrum sativum</i> L.) is a valuable spice crop prized for its culinary utility and presence of health-promoting essential oil (EO). In the present study we have evaluated the seed EO content and phytochemical profiles of 32 diverse accessions of coriander, from the National Gene Bank of India. The EO yield ranged from 0.10% to 0.50% (v/w; mean: 0.32%), with accessions IC0067147, IC0313466, and AGCr-1 exhibiting the highest content (0.50%), and IC143740 and IC0280067 the lowest (0.10%). Gas Chromatography-Mass Spectrometry (GC-MS) based profiling identified 16 constituents in the EO, dominated by the terpene alcohol linalool (mean: 83.46%). Notably, the accession IC0143593 yielded 92.32% linalool, representing the second-highest concentration reported in coriander literature to date. Correlation analysis revealed that linalool is negatively correlated to the terpene hydrocarbons, such as camphene (-0.73) and α-pinene (-0.51) (p value ≤ 0.01). Cluster analysis depicted the presence of nine different clusters with cluster two containing the highest number of accessions (11), with the highest mean linalool content of 90%. Furthermore, in silico molecular docking analysis depicted that geranyl acetate exhibited the strongest inhibitory activity against the key carbohydrate-digesting enzymes, α-amylase and α-glucosidase, demonstrating the antiglycemic potential of the oil. These findings highlight significant phytochemical variability of EO within the germplasm, offering promising candidates for commercial extraction and facilitating the execution of focused quality enhancement initiatives designed to improve the quality and composition of EO in coriander.</p>

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Essential oil profiling and in silico docking analysis reveals the antiglycemic potential of coriander (Coriandrum sativum L.)

  • 期刊论文

  • 发表日期：

    2026年7月30日

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  • Nitika Kalia,
  • Swetesh John,
  • Shailendra Saxena,
  • Narender Pal,
  • Sheel Yadav,
  • Wanchha Maurya,
  • Veena Gupta,
  • Ambika Baldev Gaikwad

摘要

Coriander (Coriandrum sativum L.) is a valuable spice crop prized for its culinary utility and presence of health-promoting essential oil (EO). In the present study we have evaluated the seed EO content and phytochemical profiles of 32 diverse accessions of coriander, from the National Gene Bank of India. The EO yield ranged from 0.10% to 0.50% (v/w; mean: 0.32%), with accessions IC0067147, IC0313466, and AGCr-1 exhibiting the highest content (0.50%), and IC143740 and IC0280067 the lowest (0.10%). Gas Chromatography-Mass Spectrometry (GC-MS) based profiling identified 16 constituents in the EO, dominated by the terpene alcohol linalool (mean: 83.46%). Notably, the accession IC0143593 yielded 92.32% linalool, representing the second-highest concentration reported in coriander literature to date. Correlation analysis revealed that linalool is negatively correlated to the terpene hydrocarbons, such as camphene (-0.73) and α-pinene (-0.51) (p value ≤ 0.01). Cluster analysis depicted the presence of nine different clusters with cluster two containing the highest number of accessions (11), with the highest mean linalool content of 90%. Furthermore, in silico molecular docking analysis depicted that geranyl acetate exhibited the strongest inhibitory activity against the key carbohydrate-digesting enzymes, α-amylase and α-glucosidase, demonstrating the antiglycemic potential of the oil. These findings highlight significant phytochemical variability of EO within the germplasm, offering promising candidates for commercial extraction and facilitating the execution of focused quality enhancement initiatives designed to improve the quality and composition of EO in coriander.