<p>Chromium (Cr) is a heavy metal that pollutes soil and harms agriculture. Its accumulation in crops reduces plant growth and development. Salicylic acid (SA) is an essential plant hormone that may minimize impacts against different abiotic stressors in plants, although its study to increase Cr stress tolerance in pea plants remains elusive. Therefore, exogenous SA therapy was performed on pea plants during Cr stress in the current work. Here, we grew a hydroponic pea cultivar, HFP8909, under different Cr treatments: 0, 0.15, 0.3 mM of Cr⁶⁺ and 1, 2, and 3 mM of Cr³⁺ with or without 0.5- and 1-mM SA. In the present work, we examined morphological, physiological and biochemical parameters, including translocation factor, MG content, protein oxidation, glutathione biosynthesis, and cell death. We also estimated the activity of antioxidant enzymes (including ascorbate peroxidase, polyphenol oxidase, and glutathione peroxidase). The results showed that Cr stress decreased plant growth traits and starch content, whereas MG content, protein oxidation and relative membrane permeability increased compared to the control plants. Meanwhile, exogenous SA (1 mM) may enhance the biological response of pea plants by increasing thiol content, promoting glutathione metabolism, and stimulating the antioxidant system, which reduces oxidative damage, prevents extensive Cr translocation, and lowers Cr toxicity. Overall, exogenous SA (1 mM) reduces the toxic effects. The outcomes revealed the first insights into the modulating process of Cr stress tolerance in pea plants by exogenous SA (1 mM). This could bring beneficial consequences for handling various Cr-stressed plants.</p>