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<p>Lanthanum oxide nanoparticle (La<sub>2</sub>O<sub>3</sub> NPs) were synthesized by co-precipitation technique using <i>Plectranthus amboinicus</i> (<i>P. amboinicus</i> ) leaf extract. A yellowish green color was observed after the addition of leaf extract to the NaOH solution. The synthesis of nanoparticles plays a vital role in the field of science and technology. The cubic structure of the La<sub>2</sub>O<sub>3</sub> was confirmed by Powder XRD. The functional groups present in the NPs were confirmed by FT-IR spectroscopy. The absorbance spectrum was observed at 274&#xa0;nm in the wavelength range of 230–850&#xa0;nm. The calculated band gap value was 4.32&#xa0;eV. The structural morphology of La<sub>2</sub>O<sub>3</sub> NPs was observed as cubic and irregular shape obtained from SEM image and EDAX spectrum which confirms the presence of La and O elements. The average particle sizes of the NPs were observed to be 40.22&#xa0;nm analyzed by high resolution transmission electron microscopy (HR-TEM) analysis. The main objective of this research work was focused on prepared La<sub>2</sub>O<sub>3</sub> NPs act as a potential inhibitor to handle various inflammations and diabetes problems. Bovine serum albumin (BSA) denaturation approach produced a strong anti-inflammatory response with 92.89% inhibition at 500&#xa0;µg/mL while α-amylase showed significant antidiabetic activity of about 94.55% inhibition at 500&#xa0;µg/mL. These results suggest that the green synthesized nanoparticles can be used for α-amylase and BSA denaturation inhibitory activities, which may be crucial for biomedical applications.</p> Graphical abstract <p></p>

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Anti-inflammatory and anti-diabetic activities of lanthanum oxide nanoparticles using Plectranthus amboinicus leaf extract

  • 期刊论文

  • 发表日期：

    2026年3月5日

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  • Kousalya Devi Vijayan,
  • Nivedhitha Bharathi Alagarsamy,
  • Sambasivam Sangaraju,
  • Venkatesan Arumugam,
  • Krishna Kumar Muthusamy,
  • Sudhahar Sakkarapani

摘要

Lanthanum oxide nanoparticle (La2O3 NPs) were synthesized by co-precipitation technique using Plectranthus amboinicus (P. amboinicus ) leaf extract. A yellowish green color was observed after the addition of leaf extract to the NaOH solution. The synthesis of nanoparticles plays a vital role in the field of science and technology. The cubic structure of the La2O3 was confirmed by Powder XRD. The functional groups present in the NPs were confirmed by FT-IR spectroscopy. The absorbance spectrum was observed at 274 nm in the wavelength range of 230–850 nm. The calculated band gap value was 4.32 eV. The structural morphology of La2O3 NPs was observed as cubic and irregular shape obtained from SEM image and EDAX spectrum which confirms the presence of La and O elements. The average particle sizes of the NPs were observed to be 40.22 nm analyzed by high resolution transmission electron microscopy (HR-TEM) analysis. The main objective of this research work was focused on prepared La2O3 NPs act as a potential inhibitor to handle various inflammations and diabetes problems. Bovine serum albumin (BSA) denaturation approach produced a strong anti-inflammatory response with 92.89% inhibition at 500 µg/mL while α-amylase showed significant antidiabetic activity of about 94.55% inhibition at 500 µg/mL. These results suggest that the green synthesized nanoparticles can be used for α-amylase and BSA denaturation inhibitory activities, which may be crucial for biomedical applications.

Graphical abstract