Scholarlink

<p>Cocaine-induced dermatomucositis is a recently described clinical entity with significant controversy regarding its diagnostic criteria and pathophysiology. While previous reports have identified a distinct pattern of chronic inflammatory mucocutaneous lesions in people who use cocaine, the absence of standardized diagnostic markers has led to inconsistencies in classification. This case series aims to clarify and unify the defining characteristics of cocaine-induced dermatomucositis by analyzing its clinical presentations, histopathologic findings, and immunologic features. Notably, we introduce immunoglobulin&#xa0;G4 (IgG4) positivity as a newly observed characteristic, challenging previous assumptions that excluded IgG4-related immune responses from its pathogenesis. By consolidating clinical and histologic patterns, this study contributes to the ongoing effort to establish cocaine-induced dermatomucositis as a distinct and recognizable disorder, paving the way for improved diagnosis and management.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Cocaine-Induced Dermatomucositis: Clarifying Diagnostic Controversies and Introducing IgG4 Positivity as a New Histopathological Feature

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月19日

查看全文
  • Francisco Reyes Albaladejo,
  • Miguel Mansilla-Polo,
  • Rafael Botella-Estrada

摘要

Cocaine-induced dermatomucositis is a recently described clinical entity with significant controversy regarding its diagnostic criteria and pathophysiology. While previous reports have identified a distinct pattern of chronic inflammatory mucocutaneous lesions in people who use cocaine, the absence of standardized diagnostic markers has led to inconsistencies in classification. This case series aims to clarify and unify the defining characteristics of cocaine-induced dermatomucositis by analyzing its clinical presentations, histopathologic findings, and immunologic features. Notably, we introduce immunoglobulin G4 (IgG4) positivity as a newly observed characteristic, challenging previous assumptions that excluded IgG4-related immune responses from its pathogenesis. By consolidating clinical and histologic patterns, this study contributes to the ongoing effort to establish cocaine-induced dermatomucositis as a distinct and recognizable disorder, paving the way for improved diagnosis and management.