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<p>Optical coherence tomography (OCT) is a non-invasive imaging modality providing real-time micrometer-scale resolution without conventional tissue processing. This study evaluated the diagnostic potential of OCT for distinguishing normal thyroid tissue from a broad spectrum of thyroid carcinomas in a pathological context. OCT imaging was performed on formalin-fixed thyroid specimens from 41 cases, including papillary (PTC, <i>n</i> = 11), follicular (FTC, <i>n</i> = 6), oncocytic (OCA, <i>n</i> = 3), anaplastic (ATC, <i>n</i> = 9), and medullary thyroid carcinoma (MTC, <i>n</i> = 12), with corresponding hematoxylin and eosin sections for correlation. Quantitative parameters were developed or adopted, including surface irregularity, penetration depth, tissue brightness, and gray-level co-occurrence matrix texture features. Qualitative analysis demonstrated visualization of tumor-specific architectural patterns, while three-dimensional reconstruction enabled depth-resolved assessment of capsular invasion and peri-capsular vascular structures. All quantitative metrics significantly differentiated carcinoma from normal tissue and showed discriminative capability across carcinoma subtypes. These findings highlight OCT as a high-resolution, label-free modality with utility in thyroid cancer diagnosis.</p>

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Optical coherence tomography for broad spectrum of thyroid carcinoma: a qualitative and quantitative analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月18日

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  • Woojin Lee,
  • Soonyong Kwon,
  • Hyeong Soo Nam,
  • Hongki Yoo,
  • Jae Yeon Seok

摘要

Optical coherence tomography (OCT) is a non-invasive imaging modality providing real-time micrometer-scale resolution without conventional tissue processing. This study evaluated the diagnostic potential of OCT for distinguishing normal thyroid tissue from a broad spectrum of thyroid carcinomas in a pathological context. OCT imaging was performed on formalin-fixed thyroid specimens from 41 cases, including papillary (PTC, n = 11), follicular (FTC, n = 6), oncocytic (OCA, n = 3), anaplastic (ATC, n = 9), and medullary thyroid carcinoma (MTC, n = 12), with corresponding hematoxylin and eosin sections for correlation. Quantitative parameters were developed or adopted, including surface irregularity, penetration depth, tissue brightness, and gray-level co-occurrence matrix texture features. Qualitative analysis demonstrated visualization of tumor-specific architectural patterns, while three-dimensional reconstruction enabled depth-resolved assessment of capsular invasion and peri-capsular vascular structures. All quantitative metrics significantly differentiated carcinoma from normal tissue and showed discriminative capability across carcinoma subtypes. These findings highlight OCT as a high-resolution, label-free modality with utility in thyroid cancer diagnosis.