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<p>Adhesive hydrogels have seen rapid advancement through the development of innovative adhesion strategies and versatile fabrication techniques, enabling robust tissue integration and localized therapeutic delivery. In regenerative medicine, muscle tissue regeneration has emerged as a key application area where these materials can promote repair, enhance bio-integration, and support functional recovery. This review summarizes recent progress in the design of adhesive hydrogels, including structural strategies for tissue-specific adhesion and fabrication methods for various hydrogel platforms. Key physicochemical properties, representative biomedical applications, and design principles for optimizing muscle regeneration are discussed, providing a concise yet comprehensive overview of their translational potential in clinical settings. Key design principles for optimizing muscle regeneration are discussed, with particular emphasis on their underlying physicochemical properties and representative biomedical applications, providing a concise yet comprehensive overview of their translational potential in clinical settings.</p>

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Recent strategies for designing adhesive hydrogels to enhance muscle tissue regeneration

  • 期刊论文

  • 发表日期：

    2026年1月2日

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  • Yesung Lee,
  • Youbin Park,
  • Mikyung Shin

摘要

Adhesive hydrogels have seen rapid advancement through the development of innovative adhesion strategies and versatile fabrication techniques, enabling robust tissue integration and localized therapeutic delivery. In regenerative medicine, muscle tissue regeneration has emerged as a key application area where these materials can promote repair, enhance bio-integration, and support functional recovery. This review summarizes recent progress in the design of adhesive hydrogels, including structural strategies for tissue-specific adhesion and fabrication methods for various hydrogel platforms. Key physicochemical properties, representative biomedical applications, and design principles for optimizing muscle regeneration are discussed, providing a concise yet comprehensive overview of their translational potential in clinical settings. Key design principles for optimizing muscle regeneration are discussed, with particular emphasis on their underlying physicochemical properties and representative biomedical applications, providing a concise yet comprehensive overview of their translational potential in clinical settings.