<p>Conformal tissue–electrode interfaces play a vital role in the long-term high-performance operation of bioelectronic devices, enabling continuous health monitoring, precise diagnosis, and personalized therapeutics as well as human–machine interfaces in the form of electronic skin (E-skin) and prostheses. Softness and mechanical deformability of the tissue–electrode interface minimize the damage to the target tissue and allow long-term efficient signal transmission through conformal integration with dynamically moving and curved organs. We herein summarize the recent advances in the tissue–electrode interfaces for bioelectronic devices with a focus on materials, fabrication, and applications. First, we discuss material design strategies to achieve stretchable, conductive materials. Next, we present novel fabrication techniques that fulfill the requirements of tissue–electrode interfaces. Subsequently, we present the applications of these strategies to tissue–electrode interfaces, demonstrating the advancements in the functional properties of these interfaces. Finally, we conclude with a summary and a discussion on the remaining challenges and future prospects of tissue–electrode interfaces.</p>