Abstract <p>There have been concerns about possible health implications of radiofrequency electromagnetic radiation owing to increased cell phone use and proliferation of cell phone towers. The amount of RF-EMR energy absorbed in the human tissues relies on both the exposure characteristics of frequency, intensity, and exposure duration. This effect could be due to the exposure of genetic material by RF, resulting in an increased risk of cancer development and death in cells. Genetic polymorphisms involve variation in the DNA sequence in and among people, populations, or groups. These polymorphisms might contribute to susceptibility to RF effects. These genetic variations-which could be in the form of single nucleotide polymorphisms (SNPs) or copy number variations (CNVs-may occur either by a sheer chance process or by external factors such as viruses or radiation. Knowing the influence of genetic polymorphisms on RF exposure would help level off related health risks of cell phone use and cell towers. This scientific review examines related scientific research data about the effects that cell terminal EMR has on human genetic damage and polymorphism. We critically appraise literature and peer review journals relevant to data in assessing our current knowledge in this area. Our study reveals the fact that some studies indicate exposure to EMR does bear a relation with genetic damage, but such results should be further researched as to which health impacts they bring forward.</p> Graphical abstract <p></p>