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Objective and methods <p>Epigenetic modifications, including miRNA regulation, have been identified as significant contributors to several disorders that include malignancies. Numerous novel compounds in epigenetic modifications have recently been receiving increasing emphasis, while the role of epigenetics in the onset and progression of illnesses has been attracting more attention. The role of miRNA and other epigenetic mechanisms in chemical toxicity needs investigation. The literature over the last decade was reviewed by searching for pertinent data in a number of reviews, using Google Scholar (<a href="http://scholar.google.com">http://scholar.google.com</a>) and PubMed (<a href="http://www.ncbi.nlm.nih.gov/pubmed">http://www.ncbi.nlm.nih.gov/pubmed</a>), together with relevant journal websites for articles published in the last five years (2019–2024). The search terms were the keywords “chemical,” “toxicity,” “microRNA,” and “epigenetics.” This review summarizes that data.</p> Results and conclusion <p>MicroRNAs exhibit the characteristics due to their capacity to react to substances and their essential function in phenotypic determination. This review updates the role of miRNAs as effective instruments to elucidate the mechanisms behind the pathophysiological response to toxicants and the prognostic significance of their expression patterns linked to specific exposures. The mechanistic data related to the involvement of miRNAs in the development of occupational illnesses were examined. It is becoming increasingly evident that miRNAs serve as significant epigenetic regulators of physiological functions. Existing research concerning the impact of xenobiotics on miRNA expression patterns was also examined.</p>

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Literature review of the microRNA regulation of chemical toxicity

  • 期刊论文

  • 发表日期：

    2025年5月21日

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  • Kyung-Taek Rim

摘要

Objective and methods

Epigenetic modifications, including miRNA regulation, have been identified as significant contributors to several disorders that include malignancies. Numerous novel compounds in epigenetic modifications have recently been receiving increasing emphasis, while the role of epigenetics in the onset and progression of illnesses has been attracting more attention. The role of miRNA and other epigenetic mechanisms in chemical toxicity needs investigation. The literature over the last decade was reviewed by searching for pertinent data in a number of reviews, using Google Scholar (http://scholar.google.com) and PubMed (http://www.ncbi.nlm.nih.gov/pubmed), together with relevant journal websites for articles published in the last five years (2019–2024). The search terms were the keywords “chemical,” “toxicity,” “microRNA,” and “epigenetics.” This review summarizes that data.

Results and conclusion

MicroRNAs exhibit the characteristics due to their capacity to react to substances and their essential function in phenotypic determination. This review updates the role of miRNAs as effective instruments to elucidate the mechanisms behind the pathophysiological response to toxicants and the prognostic significance of their expression patterns linked to specific exposures. The mechanistic data related to the involvement of miRNAs in the development of occupational illnesses were examined. It is becoming increasingly evident that miRNAs serve as significant epigenetic regulators of physiological functions. Existing research concerning the impact of xenobiotics on miRNA expression patterns was also examined.