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&#xa0;Background.&#xa0; <p>Secreted Protein Acidic and Rich in Cysteine (SPARC/osteonectin) is a matricellular protein involved in extracellular matrix remodeling and metabolic regulation.&#xa0;</p> Objective <p>This study evaluated the association between serum SPARC levels and metabolic parameters in type 2 diabetes mellitus (T2DM).</p> Methods <p>A cross-sectional case–control design was used, including 108 patients with T2DM and 105 healthy controls. Sociodemographic, anthropometric, and laboratory data were collected. Serum SPARC was measured using a commercial sandwich ELISA kit (YL Biont, China). Associations between SPARC and metabolic indicators were analyzed, with subgroup comparisons by HOMA-IR, HbA1c, BMI, diabetes duration, and age.</p> Results <p>Compared with controls, patients with T2DM had lower SPARC levels and a more adverse metabolic profile, including higher TC, LDL-C, fasting glucose, HbA1c, insulin, and HOMA-IR and lower HDL-C (all <i>p</i> &lt; 0.001). In T2DM, SPARC was inversely correlated with TC, LDL-C, fasting glucose, HbA1c, BMI, insulin, HOMA-IR, and diabetes duration, and positively correlated with age (all <i>p</i> &lt; 0.05). SPARC levels were also lower in participants with HOMA-IR ≥ 2.5, HbA1c ≥ 7%, BMI ≥ 30&#xa0;kg/m<sup>2</sup>, and diabetes duration ≥ 5&#xa0;years. ROC analysis showed poor standalone discrimination for SPARC (AUC = 0.276), whereas HbA1c and HOMA-IR showed excellent and moderate discrimination, respectively. After adjustment for age, sex, and BMI, SPARC remained independently associated with T2DM (OR = 0.982, 95% CI: 0.967–0.998, <i>p</i> = 0.032).</p> Conclusions <p>Circulating SPARC levels were reduced in T2DM and were associated with adverse metabolic features, including insulin resistance, hyperglycemia, obesity, and disease duration. Despite poor standalone diagnostic performance, SPARC may reflect metabolic burden and merits validation in larger longitudinal studies.</p>

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Reduced circulating SPARC levels in type 2 diabetes: associations with insulin resistance and metabolic dysregulation

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Mustafa Onmaz,
  • Duygu Eryavuz Onmaz,
  • Muhammed Ali Nalbant

摘要

 Background. 

Secreted Protein Acidic and Rich in Cysteine (SPARC/osteonectin) is a matricellular protein involved in extracellular matrix remodeling and metabolic regulation. 

Objective

This study evaluated the association between serum SPARC levels and metabolic parameters in type 2 diabetes mellitus (T2DM).

Methods

A cross-sectional case–control design was used, including 108 patients with T2DM and 105 healthy controls. Sociodemographic, anthropometric, and laboratory data were collected. Serum SPARC was measured using a commercial sandwich ELISA kit (YL Biont, China). Associations between SPARC and metabolic indicators were analyzed, with subgroup comparisons by HOMA-IR, HbA1c, BMI, diabetes duration, and age.

Results

Compared with controls, patients with T2DM had lower SPARC levels and a more adverse metabolic profile, including higher TC, LDL-C, fasting glucose, HbA1c, insulin, and HOMA-IR and lower HDL-C (all p < 0.001). In T2DM, SPARC was inversely correlated with TC, LDL-C, fasting glucose, HbA1c, BMI, insulin, HOMA-IR, and diabetes duration, and positively correlated with age (all p < 0.05). SPARC levels were also lower in participants with HOMA-IR ≥ 2.5, HbA1c ≥ 7%, BMI ≥ 30 kg/m2, and diabetes duration ≥ 5 years. ROC analysis showed poor standalone discrimination for SPARC (AUC = 0.276), whereas HbA1c and HOMA-IR showed excellent and moderate discrimination, respectively. After adjustment for age, sex, and BMI, SPARC remained independently associated with T2DM (OR = 0.982, 95% CI: 0.967–0.998, p = 0.032).

Conclusions

Circulating SPARC levels were reduced in T2DM and were associated with adverse metabolic features, including insulin resistance, hyperglycemia, obesity, and disease duration. Despite poor standalone diagnostic performance, SPARC may reflect metabolic burden and merits validation in larger longitudinal studies.