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Background <p>Diabetes mellitus is one of the fastest growing diseases worldwide. Peripheral neuropathy, a major microvascular complication, affecting almost 50% of diabetic patients presents significant challenge due to lack of diagnostic and therapeutic options.</p> Objective <p>The present study aims to explore the roles of excess or deficiency of micronutrients with dysregulation of inflammatory markers in the pathogenesis and progression of diabetic peripheral neuropathy.</p> Methods <p>180 subjects were recruited for the study and were divided in three groups of 60 each: diabetic subjects with neuropathy, diabetic subjects without neuropathy and non-diabetic, healthy controls. Serum micronutrients, namely, Zinc, Copper, Iron, Chromium, Selenium and Magnesium were measured by ICP-MS and inflammatory markers TNF-α and VEGF were analysed by ELISA.</p> Results <p>The data obtained were analysed using appropriate parametric and non-parametric statistical tests. Demographic trends showed a statistically significant difference between ages, gender and disease duration within the study groups (<i>p</i> ≤ 0.05). The mean serum TNF-α and CRP levels were significantly higher in patients with diabetic neuropathy (<i>p</i> ≤ 0.05) as compared to the non-neuropathy and non-diabetic control groups. Altered levels of serum micronutrients namely, Zinc, Copper, Chromium, Selenium and Iron were observed within the three study groups.</p> Conclusion <p>It is evident from the study that altered levels of micronutrients and inflammatory markers are present in diabetic complication of neuropathy. However, further studies on large populations are required to proficiently establish the diagnostic and therapeutic benefits.</p>

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A cross-sectional study on micronutrient imbalance and inflammatory dysregulation in diabetic peripheral neuropathy

  • 期刊论文

  • 发表日期：

    2026年5月1日

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  • Subhamon Bhattacherjee,
  • Ashu Rastogi,
  • Prasenjit Mitra,
  • Sanniya Middha,
  • Shania Vij,
  • Aastha Takkar,
  • Deepy Zohmangaihi

摘要

Background

Diabetes mellitus is one of the fastest growing diseases worldwide. Peripheral neuropathy, a major microvascular complication, affecting almost 50% of diabetic patients presents significant challenge due to lack of diagnostic and therapeutic options.

Objective

The present study aims to explore the roles of excess or deficiency of micronutrients with dysregulation of inflammatory markers in the pathogenesis and progression of diabetic peripheral neuropathy.

Methods

180 subjects were recruited for the study and were divided in three groups of 60 each: diabetic subjects with neuropathy, diabetic subjects without neuropathy and non-diabetic, healthy controls. Serum micronutrients, namely, Zinc, Copper, Iron, Chromium, Selenium and Magnesium were measured by ICP-MS and inflammatory markers TNF-α and VEGF were analysed by ELISA.

Results

The data obtained were analysed using appropriate parametric and non-parametric statistical tests. Demographic trends showed a statistically significant difference between ages, gender and disease duration within the study groups (p ≤ 0.05). The mean serum TNF-α and CRP levels were significantly higher in patients with diabetic neuropathy (p ≤ 0.05) as compared to the non-neuropathy and non-diabetic control groups. Altered levels of serum micronutrients namely, Zinc, Copper, Chromium, Selenium and Iron were observed within the three study groups.

Conclusion

It is evident from the study that altered levels of micronutrients and inflammatory markers are present in diabetic complication of neuropathy. However, further studies on large populations are required to proficiently establish the diagnostic and therapeutic benefits.