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Background <p>Reliable, non-invasive methods are needed to diagnose hepatic fibrosis in the Indian population. Transient elastography (TE), shear wave elastography (SWE), and Fibrosis-4 (FIB-4) scoring are commonly used for this purpose.</p> Objective <p>This study aimed to assess and compare the diagnostic effectiveness of TE and SWE in patients with confirmed hepatic steatosis in India.</p> Methods <p>A multicenter prospective study was conducted on adults with confirmed hepatic steatosis. After informed consent was obtained, the participants underwent two diagnostic procedures and data were collected. The sensitivity and specificity of both the methods were compared using the FIB-4 score as a reference. The correlation between the three methods was assessed with chi-square statistics, and statistical significance was set at <i>p</i> &lt; 0.05.</p> Results <p>The study included 201 participants with a mean age of 49.02 ± 12.08&#xa0;years. The TE method showed higher sensitivity than the SWE method for diagnosing mild fibrosis (87.34% vs. 45.57%), whereas the SWE method had better sensitivity than TE for diagnosing severe fibrosis (78.79% vs. 54.55%). For mild hepatic fibrosis, SWE had higher specificity than TE (63.11% vs. 36.89%), whereas TE was more specific for severe hepatic fibrosis (77.98% vs. 44.05%). Significant correlations were observed between all three diagnostic methods (FIB-4 score, TE, and SWE).</p> Conclusion <p>The results indicate that TE and SWE are effective for diagnosing hepatic fibrosis in Indians with hepatic steatosis and varying fibrosis severities. These findings can aid clinicians in diagnosing hepatic fibrosis in this population in a practical setting.</p>

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Comparison of transient elastography and shear wave elastography as a routine diagnostic method for assessing liver fibrosis in Indian participants with liver steatosis

  • 期刊论文

  • 发表日期：

    2026年1月22日

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  • Mukulesh Gupta,
  • Dinesh Kumar,
  • K. P. Chandra,
  • Anuj Maheshwari

摘要

Background

Reliable, non-invasive methods are needed to diagnose hepatic fibrosis in the Indian population. Transient elastography (TE), shear wave elastography (SWE), and Fibrosis-4 (FIB-4) scoring are commonly used for this purpose.

Objective

This study aimed to assess and compare the diagnostic effectiveness of TE and SWE in patients with confirmed hepatic steatosis in India.

Methods

A multicenter prospective study was conducted on adults with confirmed hepatic steatosis. After informed consent was obtained, the participants underwent two diagnostic procedures and data were collected. The sensitivity and specificity of both the methods were compared using the FIB-4 score as a reference. The correlation between the three methods was assessed with chi-square statistics, and statistical significance was set at p < 0.05.

Results

The study included 201 participants with a mean age of 49.02 ± 12.08 years. The TE method showed higher sensitivity than the SWE method for diagnosing mild fibrosis (87.34% vs. 45.57%), whereas the SWE method had better sensitivity than TE for diagnosing severe fibrosis (78.79% vs. 54.55%). For mild hepatic fibrosis, SWE had higher specificity than TE (63.11% vs. 36.89%), whereas TE was more specific for severe hepatic fibrosis (77.98% vs. 44.05%). Significant correlations were observed between all three diagnostic methods (FIB-4 score, TE, and SWE).

Conclusion

The results indicate that TE and SWE are effective for diagnosing hepatic fibrosis in Indians with hepatic steatosis and varying fibrosis severities. These findings can aid clinicians in diagnosing hepatic fibrosis in this population in a practical setting.