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Background <p>Diabetic retinopathy (DR) is a common chronic complication of diabetes mellitus. The albumin-derived neutrophil-to-lymphocyte ratio (ALB-dNLR) is an inflammatory marker. However, the association between the ALB-dNLR and DR is unclear.</p> Objective <p>The purpose was to evaluate the association between the ALB-dNLR and DR in U.S. adults.</p> Methods <p>We used data from the National Health and Nutrition Examination Survey (NHANES) from 2005–2020 to explore the correlation between the ALB-dNLR and DR variation. We obtained data from serum samples to calculate the ALB-dNLR, as well as data on DR provided by physicians through questionnaires. The main analytical methods used in this study were multivariate logistic regression, interaction stratified analysis, restricted cubic spline (RCS), and sensitivity analyses to investigate the relationships between the ALB-dNLR and DR.</p> Results <p>A total of 4,952 participants were included. After adjusting for potential confounders, compared with the lowest Compared with the Q1 group (3.045–20.944&#xa0;g/L), the fully adjusted OR for the Q4 group (36.314–631.529&#xa0;g/L) was 0.715 (95% CI: 0.577–0.885, <i>p</i> = 0.0020). A nonlinear relationship was observed between the ALB-dNLR and DR (<i>p</i> = 0.002), with an inflection point of 29.04&#xa0;g/L. At an ALB-dNLR less than 29.04&#xa0;g/L, the OR was 0.974 for each 1-unit increase in the ALB-dNLR. Subgroup analysis and sensitivity analysis confirmed the stability of the results.</p> Conclusion <p>The ALB-dNLR exhibited an L-shaped relationship with DR, and the ALB-dNLR was negatively associated with DR when the ALB-dNLR was less than 29.04&#xa0;g/L.</p>

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Association of the albumin-derived neutrophil-to-lymphocyte ratio with diabetic retinopathy results from the NHANES

  • 期刊论文

  • 发表日期：

    2025年10月31日

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  • Na Zhang,
  • Guang-Jie Cheng,
  • Lin-Jun Du,
  • Shun-Feng Zhao,
  • Ning Feng

摘要

Background

Diabetic retinopathy (DR) is a common chronic complication of diabetes mellitus. The albumin-derived neutrophil-to-lymphocyte ratio (ALB-dNLR) is an inflammatory marker. However, the association between the ALB-dNLR and DR is unclear.

Objective

The purpose was to evaluate the association between the ALB-dNLR and DR in U.S. adults.

Methods

We used data from the National Health and Nutrition Examination Survey (NHANES) from 2005–2020 to explore the correlation between the ALB-dNLR and DR variation. We obtained data from serum samples to calculate the ALB-dNLR, as well as data on DR provided by physicians through questionnaires. The main analytical methods used in this study were multivariate logistic regression, interaction stratified analysis, restricted cubic spline (RCS), and sensitivity analyses to investigate the relationships between the ALB-dNLR and DR.

Results

A total of 4,952 participants were included. After adjusting for potential confounders, compared with the lowest Compared with the Q1 group (3.045–20.944 g/L), the fully adjusted OR for the Q4 group (36.314–631.529 g/L) was 0.715 (95% CI: 0.577–0.885, p = 0.0020). A nonlinear relationship was observed between the ALB-dNLR and DR (p = 0.002), with an inflection point of 29.04 g/L. At an ALB-dNLR less than 29.04 g/L, the OR was 0.974 for each 1-unit increase in the ALB-dNLR. Subgroup analysis and sensitivity analysis confirmed the stability of the results.

Conclusion

The ALB-dNLR exhibited an L-shaped relationship with DR, and the ALB-dNLR was negatively associated with DR when the ALB-dNLR was less than 29.04 g/L.