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Background <p>Sodium-glucose cotransporter-2 (SGLT2) inhibitors have gained significant popularity due to their proven efficacy in controlling blood glucose levels, as well as additional cardiovascular and renal benefits. Despite their therapeutic efficacy, sodium-glucose cotransporter 2 (SGLT2) inhibitors have been associated with various adverse effects. We investigated the diabetes patient who discharges pink colour semen.</p> Case presentation <p>A 47-year-old obese man with uncontrolled diabetes and a history of systemic hypertension, dyslipidemia, and hypothyroidism discharges pink semen while on treatment with empagliflozin. Urine culture, semen analysis, and CT scan of the abdomen and pelvis were performed. The urine culture result showed Klebsiella count &gt; 100,000&#xa0;IU/ml. The semen analysis revealed the colonization of <i>Serratia marcescens</i>. Imaging studies revealed an ectopic kidney but no abnormalities in the reproductive organs.</p> Conclusion <p>The sustained glycosuria with the use of empagliflozin provides a favourable environment for <i>Serratia marcescens</i> growth and proliferation. Pink semen discharge is due to the colonization of <i>Serratia marcescens</i>. In such patients, early detection and intervention are recommended to avoid serious infections.</p>

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Pink semen in a patient with diabetes mellitus an uncommon effect of a common drug:  A case report

  • 期刊论文

  • 发表日期：

    2025年11月20日

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  • Kumaravel Velayutham,
  • Gomathi Panneerselvam,
  • Balaji Ramanathan,
  • Pranav Patchavakiran

摘要

Background

Sodium-glucose cotransporter-2 (SGLT2) inhibitors have gained significant popularity due to their proven efficacy in controlling blood glucose levels, as well as additional cardiovascular and renal benefits. Despite their therapeutic efficacy, sodium-glucose cotransporter 2 (SGLT2) inhibitors have been associated with various adverse effects. We investigated the diabetes patient who discharges pink colour semen.

Case presentation

A 47-year-old obese man with uncontrolled diabetes and a history of systemic hypertension, dyslipidemia, and hypothyroidism discharges pink semen while on treatment with empagliflozin. Urine culture, semen analysis, and CT scan of the abdomen and pelvis were performed. The urine culture result showed Klebsiella count > 100,000 IU/ml. The semen analysis revealed the colonization of Serratia marcescens. Imaging studies revealed an ectopic kidney but no abnormalities in the reproductive organs.

Conclusion

The sustained glycosuria with the use of empagliflozin provides a favourable environment for Serratia marcescens growth and proliferation. Pink semen discharge is due to the colonization of Serratia marcescens. In such patients, early detection and intervention are recommended to avoid serious infections.