Objective <p>The aim of this study was to determine the prevalence of magnesium deficiency in type 2 diabetic patients and investigate its impact on glycemic control and microvascular complications.</p> Methods <p>This cross-sectional study included 256 adult type 2 diabetic patients assessed over a seven-month period. The measurement of magnesium levels was conducted using the enzymatic method.</p> Results <p>The mean age of our population was 59.5&#xa0;years. Most participants had been living with type 2 diabetes for an average of 10&#xa0;years, and their glycemic control was suboptimal, with 58.6% displaying HbA1c levels exceeding 8%. Magnesium deficiency was identified among 23.3% of the patients. Hypomagnesemia was significantly associated with the duration of diabetes (<i>p</i> = 0.027). Magnesium levels were correlated with glycemic control, showing an inverse relationship with HbA1c (r = -0.163, <i>p</i> = 0.010) and fasting blood glucose (r = -0.207, <i>p</i> = 0.001). Magnesium deficiency was also significantly associated with an increased risk of diabetic retinopathy and nephropathy, with odd ratios of 2.031 and 2.120, respectively.</p> Conclusion <p>Our study highlights the high prevalence of magnesium deficiency in type 2 diabetic patients and its significant association with poor glycemic control and microangiopathic complications.</p>

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Magnesium deficiency in type 2 diabetes and its impact on glycemic control and microangiopathic complications

  • Imen Rojbi,
  • Marwa Majdoub,
  • Kahena Bouzid,
  • Sabrine Mekni,
  • Sawssen Essayeh,
  • Karima Khiari,
  • Ibtissem Ben Nacef

摘要

Objective

The aim of this study was to determine the prevalence of magnesium deficiency in type 2 diabetic patients and investigate its impact on glycemic control and microvascular complications.

Methods

This cross-sectional study included 256 adult type 2 diabetic patients assessed over a seven-month period. The measurement of magnesium levels was conducted using the enzymatic method.

Results

The mean age of our population was 59.5 years. Most participants had been living with type 2 diabetes for an average of 10 years, and their glycemic control was suboptimal, with 58.6% displaying HbA1c levels exceeding 8%. Magnesium deficiency was identified among 23.3% of the patients. Hypomagnesemia was significantly associated with the duration of diabetes (p = 0.027). Magnesium levels were correlated with glycemic control, showing an inverse relationship with HbA1c (r = -0.163, p = 0.010) and fasting blood glucose (r = -0.207, p = 0.001). Magnesium deficiency was also significantly associated with an increased risk of diabetic retinopathy and nephropathy, with odd ratios of 2.031 and 2.120, respectively.

Conclusion

Our study highlights the high prevalence of magnesium deficiency in type 2 diabetic patients and its significant association with poor glycemic control and microangiopathic complications.