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Introduction <p>Diabetic kidney disease (DKD) is one of the most common microvascular complications and affects approximately 40% of individuals with diabetes. DKD is often characterized by a persistent reduction in glomerular filtration rate (GFR &lt; 60&#xa0;mL/min/1.73 m<sup>2</sup>) and/or albuminuria. These hemodynamic changes can be detected using Doppler ultrasound, a non-invasive imaging modality. The intra-renal resistive index (RI), derived from Doppler sonography, reflects vascular resistance in the renal parenchyma and can be a very sensitive non-invasive marker for assessing nephropathy-related alterations.</p> Methods <p>This study was designed to compare renal arterial resistive index values across different stages of DKD (Stages G1 to G4 per KDIGO 2012) and assess the potential of RI as a non-invasive marker for monitoring renal disease progression, enrolling 100 patients diagnosed with diabetic kidney disease.</p> Results <p>The overall mean RI in the cohort was 0.71 ± 0.06, with stage-wise means as follows: stage 1, 0.65 ± 0.05; stage 2, 0.70 ± 0.06; stage 3, 0.74 ± 0.03; and stage 4, 0.76 ± 0.03. Linear regression analysis demonstrated a significant inverse association between eGFR and RI (<i>β</i> =  − 0.00133, 95% CI − 0.00165 to − 0.00101, <i>p</i> &lt; 0.001). One-way ANOVA showed significant variation in RI across DKD stages (<i>F</i> = 28.54, <i>p</i> &lt; 0.001).</p> Conclusion <p>This study supports the consideration of RI as a supplementary marker for DKD staging and monitoring, particularly in resource-limited settings where early detection is critical and crucial.</p>

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Evaluating intra-renal resistive index as a non-invasive marker for declining eGFR and progression of diabetic kidney disease

  • 期刊论文

  • 发表日期：

    2025年8月16日

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  • Rajeev Chawla,
  • Saumyabrata Deb,
  • Niren Garg,
  • Jatin Dhingra,
  • Shalini Jaggi,
  • Shubhaa Chawla,
  • Yejoor Chawla,
  • Chahat Jaggi

摘要

Introduction

Diabetic kidney disease (DKD) is one of the most common microvascular complications and affects approximately 40% of individuals with diabetes. DKD is often characterized by a persistent reduction in glomerular filtration rate (GFR < 60 mL/min/1.73 m2) and/or albuminuria. These hemodynamic changes can be detected using Doppler ultrasound, a non-invasive imaging modality. The intra-renal resistive index (RI), derived from Doppler sonography, reflects vascular resistance in the renal parenchyma and can be a very sensitive non-invasive marker for assessing nephropathy-related alterations.

Methods

This study was designed to compare renal arterial resistive index values across different stages of DKD (Stages G1 to G4 per KDIGO 2012) and assess the potential of RI as a non-invasive marker for monitoring renal disease progression, enrolling 100 patients diagnosed with diabetic kidney disease.

Results

The overall mean RI in the cohort was 0.71 ± 0.06, with stage-wise means as follows: stage 1, 0.65 ± 0.05; stage 2, 0.70 ± 0.06; stage 3, 0.74 ± 0.03; and stage 4, 0.76 ± 0.03. Linear regression analysis demonstrated a significant inverse association between eGFR and RI (β =  − 0.00133, 95% CI − 0.00165 to − 0.00101, p < 0.001). One-way ANOVA showed significant variation in RI across DKD stages (F = 28.54, p < 0.001).

Conclusion

This study supports the consideration of RI as a supplementary marker for DKD staging and monitoring, particularly in resource-limited settings where early detection is critical and crucial.