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Background <p>The autonomous nervous system (ANS) function is a valid parameter for evaluating cardiorespiratory efficiency index (VO<sub>2peak</sub>). ANS function is usually assessed through mean heart rate (HR) or heart rate variability (HRV).</p> Objective <p>The aim of this study was to investigate the relationship between a range of cardiac autonomic function indices and VO<sub>2peak</sub> to assess the predictors of cardiopulmonary efficiency during rest, peak exercise performance, and recovery in adolescent males with type 1 diabetes (T1D).</p> Methods <p>This cross-sectional study recruited 60 adolescent male participants with T1D (age, 15.3 ± 1.4; mean duration of diagnosis, 6.4 ± 1). A profile of cardiac autonomic indices related to HR and HRV was measured during rest, exercise, and recovery conditions. VO<sub>2peak</sub> was evaluated using Graded Exercise Testing (GXT).</p> Results <p>Simple linear regression models indicated a significant correlation between VO<sub>2peak</sub> and high-frequency power (HF) and ratio of low- to high-frequency power (LF/HF) indices at rest, peak exercise, and recovery; average HR and RMSSD at rest and recovery; and standard deviation of all normal R-R intervals (SDNN) at rest (<i>R</i> coefficients ranged from 0.90 to 0.32, <i>p</i> &lt; 0.05). The multiple linear regression model indicated the HF during recovery as an independent predictor for VO<sub>2peak</sub> (<i>R</i><sup>2</sup> = 0.86, <i>R</i> = 0.93, <i>p</i> &lt; 0.001).</p> Conclusion <p>HF appears to be a more suitable predictor of the cardiorespiratory system efficiency in the resting and recovery stages of exercise than the HR factor. The quantification of selected HRV time and frequency factors may provide clinicians with more insightful information about the cardiovascular health status of adolescents with T1D during standard exercise and subsequent recovery period.</p> Trial registration <p>Has been approved by the Iranian Registry of Clinical Trials at 2024–04-17. IRCT20211031052926N2. <a href="https://irct.behdasht.gov.ir/trial/75288">https://irct.behdasht.gov.ir/trial/75288</a></p>

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Evaluation of cardiac autonomic nervous system activity and cardiopulmonary fitness in type 1 diabetes: A cross-sectional study

  • 期刊论文

  • 发表日期：

    2025年4月4日

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  • Hossein Saki,
  • Farzad Nazem,
  • Farnaz Fariba,
  • Omid Khaiyat,
  • Ghodratollah Roshanaei

摘要

Background

The autonomous nervous system (ANS) function is a valid parameter for evaluating cardiorespiratory efficiency index (VO2peak). ANS function is usually assessed through mean heart rate (HR) or heart rate variability (HRV).

Objective

The aim of this study was to investigate the relationship between a range of cardiac autonomic function indices and VO2peak to assess the predictors of cardiopulmonary efficiency during rest, peak exercise performance, and recovery in adolescent males with type 1 diabetes (T1D).

Methods

This cross-sectional study recruited 60 adolescent male participants with T1D (age, 15.3 ± 1.4; mean duration of diagnosis, 6.4 ± 1). A profile of cardiac autonomic indices related to HR and HRV was measured during rest, exercise, and recovery conditions. VO2peak was evaluated using Graded Exercise Testing (GXT).

Results

Simple linear regression models indicated a significant correlation between VO2peak and high-frequency power (HF) and ratio of low- to high-frequency power (LF/HF) indices at rest, peak exercise, and recovery; average HR and RMSSD at rest and recovery; and standard deviation of all normal R-R intervals (SDNN) at rest (R coefficients ranged from 0.90 to 0.32, p < 0.05). The multiple linear regression model indicated the HF during recovery as an independent predictor for VO2peak (R2 = 0.86, R = 0.93, p < 0.001).

Conclusion

HF appears to be a more suitable predictor of the cardiorespiratory system efficiency in the resting and recovery stages of exercise than the HR factor. The quantification of selected HRV time and frequency factors may provide clinicians with more insightful information about the cardiovascular health status of adolescents with T1D during standard exercise and subsequent recovery period.

Trial registration

Has been approved by the Iranian Registry of Clinical Trials at 2024–04-17. IRCT20211031052926N2. https://irct.behdasht.gov.ir/trial/75288