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Background <p>Type 2 diabetes mellitus (T2DM) is one of the most prevalent metabolic disorders, characterized by insulin resistance and chronic hyperglycemia. Recent studies have suggested that small intestinal bacterial overgrowth (SIBO) may influence glycemic control and gastrointestinal complications in diabetic patients. However, the precise relationship between SIBO and hemoglobin A1C (HbA1c) levels remains inadequately explored.</p> Objective <p>The study aims to fill research gaps in Ahvaz, Iran, on the relationship between glycemic control and factors in diabetes patients with small intestinal bacterial overgrowth (SIBO) syndrome.</p> Methods <p>This epidemiologic study, applying a descriptive-analytical cross-sectional research design, was performed on type 2 diabetes mellitus (T2DM) patients recruited based on the inclusion criteria, including, suffering from T2DM as diagnosed by an endocrinologist, having a history of Gastrointestinal (GI) symptoms, and being at the age range of 18–65 years. Upon signing a written informed consent form, the patient’s baseline characteristics were checked and then imported into the data collection tool. The patients were subsequently divided into two groups as specified by glycemic control and hemoglobin A1C (HbA1C) level, namely, Group I (<i>n</i> = 40) consisting of the T2DM patients with reasonable glycemic control (HbA1C≤7.5) and Group II (<i>n</i> = 40) comprised of the T2DM patients with poor glycemic control (HbA1C&gt;7.5). Ultimately, the prevalence rate of SIBO coupled with the role of various factors in the relationship between glycemic control and the given syndrome were compared in both study groups.</p> Results <p>The study results revealed that the prevalence rate of the SIBO syndrome was higher (<i>p</i>-value = 0.025) in T2DM patients with poor glycemic control, but this relationship could vary based on some associated factors, such as age, gender, disease duration, and even smoking.</p> Conclusion <p>The study explores the link between T2DM and SIBO, emphasizing the importance of glycemic control in preventing symptoms and improving patient quality of life, particularly considering SIBO syndrome.</p>

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Investigating the relationship between small intestinal bacterial overgrowth and hemoglobin A1C level in patients with type 2 diabetes mellitus: An epidemiologic study in Ahvaz, Iran

  • 期刊论文

  • 发表日期：

    2025年2月21日

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  • Mehrnoosh Zakerkish,
  • Seyed Arman Saeedi,
  • Seyed Saeed Seyedian,
  • Golshan Mirmomeni

摘要

Background

Type 2 diabetes mellitus (T2DM) is one of the most prevalent metabolic disorders, characterized by insulin resistance and chronic hyperglycemia. Recent studies have suggested that small intestinal bacterial overgrowth (SIBO) may influence glycemic control and gastrointestinal complications in diabetic patients. However, the precise relationship between SIBO and hemoglobin A1C (HbA1c) levels remains inadequately explored.

Objective

The study aims to fill research gaps in Ahvaz, Iran, on the relationship between glycemic control and factors in diabetes patients with small intestinal bacterial overgrowth (SIBO) syndrome.

Methods

This epidemiologic study, applying a descriptive-analytical cross-sectional research design, was performed on type 2 diabetes mellitus (T2DM) patients recruited based on the inclusion criteria, including, suffering from T2DM as diagnosed by an endocrinologist, having a history of Gastrointestinal (GI) symptoms, and being at the age range of 18–65 years. Upon signing a written informed consent form, the patient’s baseline characteristics were checked and then imported into the data collection tool. The patients were subsequently divided into two groups as specified by glycemic control and hemoglobin A1C (HbA1C) level, namely, Group I (n = 40) consisting of the T2DM patients with reasonable glycemic control (HbA1C≤7.5) and Group II (n = 40) comprised of the T2DM patients with poor glycemic control (HbA1C>7.5). Ultimately, the prevalence rate of SIBO coupled with the role of various factors in the relationship between glycemic control and the given syndrome were compared in both study groups.

Results

The study results revealed that the prevalence rate of the SIBO syndrome was higher (p-value = 0.025) in T2DM patients with poor glycemic control, but this relationship could vary based on some associated factors, such as age, gender, disease duration, and even smoking.

Conclusion

The study explores the link between T2DM and SIBO, emphasizing the importance of glycemic control in preventing symptoms and improving patient quality of life, particularly considering SIBO syndrome.