<p>Rice holds a critical status as a primary food source for more than half of the global population, and its consumption continues to rise in response to growing populations worldwide. Consequently, this upsurge in rice production yields a substantial amount of rice husks (RHs) as a byproduct. Addressing the environmental challenges RH disposal poses, this paper explores a sustainable approach to harness the untapped potential of RHs. By employing the sol–gel method, RHs are transformed into mesoporous silica nanoparticles. This study advocates for the environmentally-friendly utilization of RHs in nanomaterial synthesis, promoting resource efficiency and reducing environmental pollution. The findings underscore the significance of repurposing agricultural waste as valuable materials, contributing to sustainable production methods for a greener future. A wide range of analytical techniques were employed to comprehensively evaluate the nanoparticles, including transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDX), dynamic light scattering (DLS), X-ray fluorescence (XRF), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Barrett-Joyner-Halenda (BJH) method, and Brunauer–Emmett–Teller (BET) analysis. The results revealed that the nanoparticles exhibit an amorphous phase, with hydroxyl functional groups placed on their surface. DLS analysis determined The size distribution, which showed a range varying from 3.7 to 5.7 nm, with an average size (D50) of approximately 14.6 nm and a size (D90) of about 23 nm. Furthermore, the assessment of nanoparticle purity, specific surface area (SSA), and total pore volume resulted in 98.41%, 867.52 m²/g, and 16.701 m³/g, respectively. The nanoparticles produced in this study exhibit a high surface area and controlled mesoporous structure, providing superior porosity and surface properties.</p>