Let \(\Omega \) be an irreducible bounded symmetric domain in \(\mathbb {C}^n\) . Let \(\alpha >-\,1\) , \(1<p,q<\infty \) with \(\begin{aligned} \frac{a(r-1)}{2}<\frac{\alpha +1+\frac{a(r-1)}{2}}{q}<\alpha +1. \end{aligned}\) We characterize the bounded little Hankel operators acting from the Bergman space \(A_\alpha ^p(\Omega )\) to \(\overline{A_\alpha ^q(\Omega )}\) . As an application, we give a weak factorization of the Bergman space \(A^p_\alpha (\Omega )\) for some \(p>1\) .