<p>Aqueous zinc-ion batteries (ZIBs) have emerged as a highly promising candidate for next-generation energy storage systems, owing to their inherent cost-effectiveness, exceptional safety, and environmental benignity. However, the sluggish development of high-performance cathode materials remains a critical bottleneck hindering the practical application of ZIBs. Herein, we report the rational design and successful synthesis of a novel high-entropy oxide, (FeMnAlCrTi)₃O₄ (denoted as FMACTO), and systematically evaluate its electrochemical performance as a cathode material for ZIBs. Benefiting from the unique multi-cation synergistic effect and lattice distortion inherent in FMACTO, the material exhibits significantly enhanced electronic conductivity and accelerated zinc-ion diffusion kinetics. As a result, FMACTO delivers a high specific capacity of 238.6 mAh g⁻¹ at a current density of 0.2&#xa0;A g⁻¹ and excellent cycling stability with 70.1% capacity retention after 1100 charge-discharge cycles. This work not only demonstrates the great potential of FMACTO as a high-performance ZIB cathode but also provides a versatile high-entropy design strategy for the development of advanced electrode materials in energy storage fields.</p> Graphical Abstract <p></p>