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<p>Despite suppression of viral replication by antiretroviral therapy (cART) HIV-associated neurocognitive disorders (HAND) may persist. This involves chronic inflammation with activation of the monocyte-macrophage-microglia axis. We examined CXCL13, a chemokine released by these cells, as a possible marker for HAND treatment response. We longitudinally analyzed cerebrospinal fluid (CSF) from before and during newly initiated cART of people living with HIV (PLWH) with HIV-associated dementia (HAD). CXCL13<sub>CSF</sub> was determined by ELISA. We studied the correlation of CXCL13<sub>CSF</sub> with HAD as measured by the Memorial Sloan Kettering score (MSK-score) and with CSF and blood parameters. Twelve treatment-naïve patients with HAD were included. Prior to cART the correlation of CXCL13<sub>CSF</sub> (τ_b = 0.575, <i>p</i> = 0.051) with MSK-score narrowly missed significance. At an average of 2,9 months after start of cART, CXCL13<sub>CSF</sub> strongly correlated with MSK-score (τ_b = 0.746, <i>p</i> = 0.005). Also, the magnitude of the longitudinal change of CXCL-13<sub>CSF</sub> correlated with the change of MSK-score (τ_b = 0.460, <i>p</i> = 0.048). No correlation was found between MSK-score and CSF white blood cell count (WBC<sub>CSF</sub>) as well as HIV-RNA (plasma, CSF). CXCL13<sub>CSF</sub> showed a significant correlation with HAD but not with WBC<sub>CSF</sub> and HIV-RNA. As CXCL13 in the CNS is secreted by macrophages and microglia our results suggest a significant role of the monocyte-macrophage-microglia axis as a line of immunological defense relatively independent of viral replication. If supported by further studies CXCL13 might serve as CSF biomarker in HIV patients with HAD.</p>

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CSF CXCL13 as a longitudinal marker for neurocognition in HIV-1-associated dementia after start of treatment in cART-naïve patients

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  • 发表日期：

    2026年3月2日

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  • Jürgen Panholzer,
  • Anna R. Tröscher,
  • Vincent Böhm,
  • Raimund Helbok,
  • Christian Eggers

摘要

Despite suppression of viral replication by antiretroviral therapy (cART) HIV-associated neurocognitive disorders (HAND) may persist. This involves chronic inflammation with activation of the monocyte-macrophage-microglia axis. We examined CXCL13, a chemokine released by these cells, as a possible marker for HAND treatment response. We longitudinally analyzed cerebrospinal fluid (CSF) from before and during newly initiated cART of people living with HIV (PLWH) with HIV-associated dementia (HAD). CXCL13CSF was determined by ELISA. We studied the correlation of CXCL13CSF with HAD as measured by the Memorial Sloan Kettering score (MSK-score) and with CSF and blood parameters. Twelve treatment-naïve patients with HAD were included. Prior to cART the correlation of CXCL13CSF (τ_b = 0.575, p = 0.051) with MSK-score narrowly missed significance. At an average of 2,9 months after start of cART, CXCL13CSF strongly correlated with MSK-score (τ_b = 0.746, p = 0.005). Also, the magnitude of the longitudinal change of CXCL-13CSF correlated with the change of MSK-score (τ_b = 0.460, p = 0.048). No correlation was found between MSK-score and CSF white blood cell count (WBCCSF) as well as HIV-RNA (plasma, CSF). CXCL13CSF showed a significant correlation with HAD but not with WBCCSF and HIV-RNA. As CXCL13 in the CNS is secreted by macrophages and microglia our results suggest a significant role of the monocyte-macrophage-microglia axis as a line of immunological defense relatively independent of viral replication. If supported by further studies CXCL13 might serve as CSF biomarker in HIV patients with HAD.