Scholarlink

<p>Mitochondrial DNA (mtDNA) in extracellular vesicles (EVs) may track HIV-related neuronal injury. We measured mtDNA copy number in neuron-derived EVs (NEVs) and total plasma EVs from 48 African American adults stratified by sex, HIV status, and smoking. NEV-mtDNA differed by group (<i>p</i> &lt; 0.05): men with HIV showed the highest levels, markedly exceeding HIV-negative men and all women, while smoking raised NEV-mtDNA only in men. Plasma EV-mtDNA paralleled NEVs but was ~ 100-fold higher, reflecting systemic release. These sex-specific increases implicate HIV as a stronger mitochondrial stressor in men and support NEV-mtDNA as a convenient biomarker of neuro-mitochondrial dysfunction.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sex-specific mitochondrial DNA changes in neuron-derived extracellular vesicles of African American adults: impact of HIV infection and smoking

  • 期刊论文

  • 发表日期：

    2025年7月25日

查看全文
  • Vladimir Berthaud,
  • Tarik Smith,
  • Venkateswara R. Amara,
  • Derek Wilus,
  • Franklin J. Nouvet,
  • Waldemar Popik

摘要

Mitochondrial DNA (mtDNA) in extracellular vesicles (EVs) may track HIV-related neuronal injury. We measured mtDNA copy number in neuron-derived EVs (NEVs) and total plasma EVs from 48 African American adults stratified by sex, HIV status, and smoking. NEV-mtDNA differed by group (p < 0.05): men with HIV showed the highest levels, markedly exceeding HIV-negative men and all women, while smoking raised NEV-mtDNA only in men. Plasma EV-mtDNA paralleled NEVs but was ~ 100-fold higher, reflecting systemic release. These sex-specific increases implicate HIV as a stronger mitochondrial stressor in men and support NEV-mtDNA as a convenient biomarker of neuro-mitochondrial dysfunction.