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<p>A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer with multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab and bendamustine had finished 6.5 years ago. Discontinuing palbociclib and using mirtazapine, she is alive a year after diagnosis of PML. It is rare for PML to be diagnosed long after the last dose of rituximab and bendamustine. We will discuss the possible involvement of palbociclib in the course of PML.</p>

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Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月21日

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  • Ryosuke Koyamada,
  • Mariko Nishihara,
  • Tetsuhiro Masaki,
  • Tomohito Shimada,
  • Kazuhiro Ishikawa,
  • Jun Hashimoto,
  • Nobuyoshi Mori,
  • Asami Namai,
  • Hideaki Yokoo,
  • Kenta Takahashi,
  • Tadaki Suzuki,
  • Kazuo Nakamichi,
  • Shinichiro Mori

摘要

A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer with multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab and bendamustine had finished 6.5 years ago. Discontinuing palbociclib and using mirtazapine, she is alive a year after diagnosis of PML. It is rare for PML to be diagnosed long after the last dose of rituximab and bendamustine. We will discuss the possible involvement of palbociclib in the course of PML.