Scholarlink

Background <p>Human herpesviruses (HHVs) are lifelong pathogens that can reactivate under stress or immunological changes. Depression has been implicated as both a potential trigger for and a consequence of HHV reactivation. This study investigates the bidirectional relationship between HHV reactivation and depression through a systematic review and meta-analysis.</p> Methods <p>This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD42024565616). A search of PubMed, Web of Science, Embase, and Scopus identified studies published through March 5, 2024.</p> Results <p>Nineteen studies, representing a total sample size of 94,194 participants, were included in the meta-analysis. The pooled odds ratio (OR) demonstrated a significant association between HHV reactivation and depression (OR = 1.33; 95% CI: 1.07–1.64; p &lt; 0.001; I<sup>2</sup> = 92%). Subgroup analyses revealed significant associations for Epstein-Barr virus (EBV) (OR = 1.99; 95% CI: 1.80–2.20) and herpes simplex virus 2 (HSV-2) (OR = 1.83; 95% CI: 1.32–2.55), while cytomegalovirus (CMV) and HSV-1 showed non-significant associations. A secondary meta-analysis found a significant association between pre-morbid depression and EBV reactivation (OR = 2.18; 95% CI: 1.48–3.21) as well as varicella-zoster virus (VZV) reactivation (HR = 1.09; 95% CI: 1.06–1.13). Sensitivity analyses confirmed the robustness of the findings, and no substantial publication bias was detected.</p> Conclusion <p>This study provides evidence of a bidirectional relationship between HHV reactivation and depression, highlighting depression as both a risk factor for and a potential consequence of HHV reactivation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bidirectional relationship between human herpes virus reactivation and depression: a systematic review and meta-analysis

  • 期刊论文

  • 发表日期：

    2025年3月26日

查看全文
  • Arman Shafiee,
  • Zahra Nakhaee,
  • Mohammad Javad Amini,
  • Fatemeh Esmailpur Abianeh,
  • Mana Goodarzi,
  • Samira Parvizi Omran,
  • Hamed Hajishah,
  • Dina Sadeghi,
  • Aida Rezaei Nejad,
  • Mahmood Bakhtiyari

摘要

Background

Human herpesviruses (HHVs) are lifelong pathogens that can reactivate under stress or immunological changes. Depression has been implicated as both a potential trigger for and a consequence of HHV reactivation. This study investigates the bidirectional relationship between HHV reactivation and depression through a systematic review and meta-analysis.

Methods

This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD42024565616). A search of PubMed, Web of Science, Embase, and Scopus identified studies published through March 5, 2024.

Results

Nineteen studies, representing a total sample size of 94,194 participants, were included in the meta-analysis. The pooled odds ratio (OR) demonstrated a significant association between HHV reactivation and depression (OR = 1.33; 95% CI: 1.07–1.64; p < 0.001; I2 = 92%). Subgroup analyses revealed significant associations for Epstein-Barr virus (EBV) (OR = 1.99; 95% CI: 1.80–2.20) and herpes simplex virus 2 (HSV-2) (OR = 1.83; 95% CI: 1.32–2.55), while cytomegalovirus (CMV) and HSV-1 showed non-significant associations. A secondary meta-analysis found a significant association between pre-morbid depression and EBV reactivation (OR = 2.18; 95% CI: 1.48–3.21) as well as varicella-zoster virus (VZV) reactivation (HR = 1.09; 95% CI: 1.06–1.13). Sensitivity analyses confirmed the robustness of the findings, and no substantial publication bias was detected.

Conclusion

This study provides evidence of a bidirectional relationship between HHV reactivation and depression, highlighting depression as both a risk factor for and a potential consequence of HHV reactivation.