Scholarlink

Background <p>The ratio of D-dimer to fibrinogen is intimately associated with the occurrence, progression, and severity of coronary artery lesions in atherosclerosis (Hou in Chin J Stroke 16:805–809, 2021; Alkhalfan in Am J Cardiol 122: 1459–1464, 2018), according to the core updates of the 2024 ESC Guidelines for the Management of Atrial Fibrillation, the old CHA2DS2—VASc score is not used, and the CHA2DS2-VA score is utilized as a tool for the assessment of cardiovascular disease. However, no analytical report has been presented about the application of both in the prediction of carotid artery stenosis in type 2 diabetes, so we aimed to explore the relationship between the combination of D-dimer/fibrinogen ratio (DFR) and CHA2DS2-VA score and carotid atherosclerosis (CAS) in patients with type 2 diabetes (T2DM).</p> Methods <p>A total of 294 patients with T2DM between January 2022 and June 2024 were categorized into three groups in accordance with the carotid intima-media thickness (CIMT),general clinical data and laboratory biochemical indicators were collected for each group, and the DFR and CHA2DS2-VA score was calculated.The ordered logistic regression was used to identify factors independently associated with carotid atherosclerosis.</p> Results <p>Among CIMT &lt; 1.0&#xa0;mm,1.0&#xa0;mm ≤ CIMT &lt; 1.5&#xa0;mm and CIMT ≥ 1.5&#xa0;mm, age, history of smoking, hypertension, insulin usage, sdLDL, HbA1c, ACR, CHA2DS2-VA score, Hcy, D-dime, DFR, and CysC gradually rose (<i>P</i> &lt; 0.05).The ordered logistic regression analysis demonstrated that age, LDL-C, hypertension, cystatin C, HbA1c, DFR, CHA2DS2-VA score, and TC constituted the influencing factors for CAS in T2DM patients.The receiver operating characteristic (ROC) curve manifested that the area under the curve for predicting CAS in T2DM patients using the combination of the CHA2DS2-VA score and DFR was 0.837, with a sensitivity of 79.5% and specificity of 81.8%.</p> Conclusions <p>The combination of DFR and CHA2DS2-VA score proved to be more reliable in predicting CAS in T2DM patients and may emerge as a new target for intervention in T2DM patients with CAS.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The combination of the D-dimer/fibrinogen ratio and the CHA2DS2-VA score is exploited for the prediction of carotid atherosclerosis in patients with type 2 diabetes mellitus: a retrospective cohort study

  • 期刊论文

  • 发表日期：

    2026年2月25日

查看全文
  • Shikai Wang,
  • Zhenzhen Long,
  • Junli Zhang,
  • Lu Jiang,
  • Lijun Hou

摘要

Background

The ratio of D-dimer to fibrinogen is intimately associated with the occurrence, progression, and severity of coronary artery lesions in atherosclerosis (Hou in Chin J Stroke 16:805–809, 2021; Alkhalfan in Am J Cardiol 122: 1459–1464, 2018), according to the core updates of the 2024 ESC Guidelines for the Management of Atrial Fibrillation, the old CHA2DS2—VASc score is not used, and the CHA2DS2-VA score is utilized as a tool for the assessment of cardiovascular disease. However, no analytical report has been presented about the application of both in the prediction of carotid artery stenosis in type 2 diabetes, so we aimed to explore the relationship between the combination of D-dimer/fibrinogen ratio (DFR) and CHA2DS2-VA score and carotid atherosclerosis (CAS) in patients with type 2 diabetes (T2DM).

Methods

A total of 294 patients with T2DM between January 2022 and June 2024 were categorized into three groups in accordance with the carotid intima-media thickness (CIMT),general clinical data and laboratory biochemical indicators were collected for each group, and the DFR and CHA2DS2-VA score was calculated.The ordered logistic regression was used to identify factors independently associated with carotid atherosclerosis.

Results

Among CIMT < 1.0 mm,1.0 mm ≤ CIMT < 1.5 mm and CIMT ≥ 1.5 mm, age, history of smoking, hypertension, insulin usage, sdLDL, HbA1c, ACR, CHA2DS2-VA score, Hcy, D-dime, DFR, and CysC gradually rose (P < 0.05).The ordered logistic regression analysis demonstrated that age, LDL-C, hypertension, cystatin C, HbA1c, DFR, CHA2DS2-VA score, and TC constituted the influencing factors for CAS in T2DM patients.The receiver operating characteristic (ROC) curve manifested that the area under the curve for predicting CAS in T2DM patients using the combination of the CHA2DS2-VA score and DFR was 0.837, with a sensitivity of 79.5% and specificity of 81.8%.

Conclusions

The combination of DFR and CHA2DS2-VA score proved to be more reliable in predicting CAS in T2DM patients and may emerge as a new target for intervention in T2DM patients with CAS.