Scholarlink

Objectives <p>To investigate whether low skeletal muscle mass predicts insulin resistance (IR) progression in non-obese older adults, and whether its coexistence with abdominal obesity further increases risk.</p> Methods <p>This six-year cohort study was part of the Tanno-Sobetsu study, a prospective cohort of 204 community-dwelling Japanese older adults aged ≥ 65&#xa0;years, enrolled in 2017 and followed through 2023. Participants were classified into four groups based on the presence or absence of low skeletal muscle mass (sex-specific lowest quartile) and abdominal obesity. IR progression was defined as HOMA-IR ≥ 1.73. Participants without IR at baseline were followed for a median of 2.8&#xa0;years. Cox proportional hazards models were used to estimate adjusted hazard ratios (HR) for IR progression, using the group with neither condition as the reference, with adjustments for age, sex, baseline HOMA-IR, and triglycerides.</p> Results <p>During follow-up, 86 participants (42.2%) developed IR. Compared to those with neither condition, low skeletal muscle mass alone was significantly associated with IR progression (HR: 2.11, 95% CI 1.08–4.11, <i>p</i> = 0.029), as was the coexistence of low skeletal muscle mass and abdominal obesity (HRs: 2.09, 95% CI 1.13–3.86, <i>p</i> = 0.019). Abdominal obesity alone was not significantly associated (HR: 1.15, 95% CI 0.61–2.15, <i>p</i> = 0.65).</p> Conclusions <p>Low skeletal muscle mass independently predicted IR progression in older adults, even in the absence of abdominal obesity. No additive risk was observed when low muscle mass coexisted with abdominal obesity after adjusting for baseline HOMA-IR. These findings support assessing muscle mass for IR prevention, regardless of abdominal obesity status.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Low skeletal muscle mass independently predicts the progression of insulin resistance in non-obese older adults: a six-year cohort study

  • 期刊论文

  • 发表日期：

    2025年8月2日

查看全文
  • Toshiaki Seko,
  • Nobuaki Himuro,
  • Masayuki Koyama,
  • Kei Nakata,
  • Hiroshi Akasaka,
  • Mitsuru Mori,
  • Shunichi Ogawa,
  • Sayo Miura,
  • Hirofumi Ohnishi

摘要

Objectives

To investigate whether low skeletal muscle mass predicts insulin resistance (IR) progression in non-obese older adults, and whether its coexistence with abdominal obesity further increases risk.

Methods

This six-year cohort study was part of the Tanno-Sobetsu study, a prospective cohort of 204 community-dwelling Japanese older adults aged ≥ 65 years, enrolled in 2017 and followed through 2023. Participants were classified into four groups based on the presence or absence of low skeletal muscle mass (sex-specific lowest quartile) and abdominal obesity. IR progression was defined as HOMA-IR ≥ 1.73. Participants without IR at baseline were followed for a median of 2.8 years. Cox proportional hazards models were used to estimate adjusted hazard ratios (HR) for IR progression, using the group with neither condition as the reference, with adjustments for age, sex, baseline HOMA-IR, and triglycerides.

Results

During follow-up, 86 participants (42.2%) developed IR. Compared to those with neither condition, low skeletal muscle mass alone was significantly associated with IR progression (HR: 2.11, 95% CI 1.08–4.11, p = 0.029), as was the coexistence of low skeletal muscle mass and abdominal obesity (HRs: 2.09, 95% CI 1.13–3.86, p = 0.019). Abdominal obesity alone was not significantly associated (HR: 1.15, 95% CI 0.61–2.15, p = 0.65).

Conclusions

Low skeletal muscle mass independently predicted IR progression in older adults, even in the absence of abdominal obesity. No additive risk was observed when low muscle mass coexisted with abdominal obesity after adjusting for baseline HOMA-IR. These findings support assessing muscle mass for IR prevention, regardless of abdominal obesity status.