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Background <p>Cost-effective, noninvasive methods to assess glycemic control can aid Diabetes Mellitus (DM) screening and management. We assess the potential of glycated protein in scalp hair as a surrogate marker for glycemic control. Using a Thiobarbituric Acid (TBA) assay, the effects of various cosmetic treatments on the hair and the mass of samples were measured.</p> Methods <p>Anthropometrics, demographics, medical history and HbA1c measurements were collected after obtaining informed consent from 192 participants. About 50 strands of hair, 4&#xa0;cm long, proximal to the scalp, were clipped and stored at − 20&#xa0;°C. The fructosamine concentration in the samples was determined using the TBA method and a fructose calibration curve. The strength of the correlation between HbA1c and fructosamine for hair samples with and without hair treatments was assessed using Pearson's R.</p> Results <p>56% of participants had a prior DM diagnosis, 61% were female and were predominantly East Indian (73%). Although no significant correlation between fructosamine and HbA1c was observed for the entire population, for the samples with no reported hair treatments, there was a statistically positive association when the sample mass ranged between 40 and 120&#xa0;mg. The highest correlation, r(28) = 0.647, <i>p</i> = &lt; 0.001 was observed when hair samples greater than 70&#xa0;mg were used for the assay.</p> Conclusion <p>Hair glycation can be a robust, noninvasive indicator of blood glucose control in optimum conditions. However, sample collection limitations, cumbersome processing, lengthy assays, and the influence of cosmetic treatments limit its usefulness as a screening tool for DM.</p>

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Glycated hair protein analysis as a noninvasive proxy for blood glucose monitoring: investigating the impact of sample mass and chemical hair treatments

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Andrew S. Dhanoo,
  • Brian N. Cockburn

摘要

Background

Cost-effective, noninvasive methods to assess glycemic control can aid Diabetes Mellitus (DM) screening and management. We assess the potential of glycated protein in scalp hair as a surrogate marker for glycemic control. Using a Thiobarbituric Acid (TBA) assay, the effects of various cosmetic treatments on the hair and the mass of samples were measured.

Methods

Anthropometrics, demographics, medical history and HbA1c measurements were collected after obtaining informed consent from 192 participants. About 50 strands of hair, 4 cm long, proximal to the scalp, were clipped and stored at − 20 °C. The fructosamine concentration in the samples was determined using the TBA method and a fructose calibration curve. The strength of the correlation between HbA1c and fructosamine for hair samples with and without hair treatments was assessed using Pearson's R.

Results

56% of participants had a prior DM diagnosis, 61% were female and were predominantly East Indian (73%). Although no significant correlation between fructosamine and HbA1c was observed for the entire population, for the samples with no reported hair treatments, there was a statistically positive association when the sample mass ranged between 40 and 120 mg. The highest correlation, r(28) = 0.647, p = < 0.001 was observed when hair samples greater than 70 mg were used for the assay.

Conclusion

Hair glycation can be a robust, noninvasive indicator of blood glucose control in optimum conditions. However, sample collection limitations, cumbersome processing, lengthy assays, and the influence of cosmetic treatments limit its usefulness as a screening tool for DM.