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Objective <p>To determine the seroprevalence of hepatitis A among non-vaccinated adolescents aged 9–12&#xa0;years and to ascertain the sociodemographic factors associated with seropositivity.</p> Methods <p>A cross-sectional study was conducted among non-vaccinated adolescents aged 9–12&#xa0;years from urban and semi-urban settings in New Delhi. Sera were analyzed using competitive ELISA to detect IgG antibodies against hepatitis A. Sociodemographic data were collected using a structured pro forma.</p> Results <p>Of the 94 participants, 85 (90.4%) were seropositive for hepatitis A. Seropositivity was significantly associated with low socioeconomic status, lower parental education levels, lower parental occupation status, and low monthly household income.</p> Conclusions <p>Despite improved sanitation, lower socioeconomic groups remain highly endemic for hepatitis A. Catch-up vaccination may have limited utility in adolescents aged 10&#xa0;years or older from these backgrounds. Targeted public health strategies and further evaluation of vaccination policies in specific populations are needed.</p> <p><i>Trial Registration</i>: Clinical Trials Registry–India No. CTRI/2022/10/046790.Obtained.</p>

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Seroprevalence of Hepatitis A in Non-vaccinated Adolescents Aged 9 to 12 Years in New Delhi, India: A Cross-Sectional Study

  • 期刊论文

  • 发表日期：

    2025年6月3日

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  • Anurag Agarwal,
  • Shweta Sajlan,
  • Rohit Chawla,
  • Surendra Bahadur Mathur

摘要

Objective

To determine the seroprevalence of hepatitis A among non-vaccinated adolescents aged 9–12 years and to ascertain the sociodemographic factors associated with seropositivity.

Methods

A cross-sectional study was conducted among non-vaccinated adolescents aged 9–12 years from urban and semi-urban settings in New Delhi. Sera were analyzed using competitive ELISA to detect IgG antibodies against hepatitis A. Sociodemographic data were collected using a structured pro forma.

Results

Of the 94 participants, 85 (90.4%) were seropositive for hepatitis A. Seropositivity was significantly associated with low socioeconomic status, lower parental education levels, lower parental occupation status, and low monthly household income.

Conclusions

Despite improved sanitation, lower socioeconomic groups remain highly endemic for hepatitis A. Catch-up vaccination may have limited utility in adolescents aged 10 years or older from these backgrounds. Targeted public health strategies and further evaluation of vaccination policies in specific populations are needed.

Trial Registration: Clinical Trials Registry–India No. CTRI/2022/10/046790.Obtained.