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Background and aim <p>Statistical cure occurs when the mortality of a specific population returns to mortality values of the general population. Whether antiviral therapy is associated with achievement of statistical cure of patients with hepatocellular carcinoma (HCC) undergoing liver resection (LR) remains unknown. We aimed to clarify this issue.</p> Methods <p>We enrolled 1004 patients with HCC who underwent LR. We evaluated overall survival (OS) as the primary survival measure for estimating cure fractions through a mixture model.</p> Results <p>The probability of resection enabling patients with HCC to achieve the same life expectancy as that of the general population was 48.6%. The multivariable cure model revealed that age ≤ 65&#xa0;years, 7th edition pathological American Joint Committee on Cancer (AJCC) stage 1, no cirrhosis, receipt of antiviral therapy, and a Model for End-Stage Liver Disease (MELD) score of ≤ 9 were predictors of cure after LR.</p> Conclusions <p>About five in 10 patients could be considered cured after LR for HCC. In addition to tumor- and liver-related variables, receipt of antiviral therapy was associated with achievement of statistical cure. We highlight the importance of antiviral therapy for maximizing outcomes of resection for HCC.</p>

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Antiviral therapy is associated with achievement of statistical cure of patients undergoing liver resection for hepatocellular carcinoma: a retrospective study

  • 期刊论文

  • 发表日期：

    2026年1月19日

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  • Yi-Hao Yen,
  • Sin-Hua Moi,
  • Yueh-Wei Liu,
  • Chee-Chien Yong,
  • Chih-Chi Wang,
  • Wei-Feng Li,
  • Chih-Yun Lin

摘要

Background and aim

Statistical cure occurs when the mortality of a specific population returns to mortality values of the general population. Whether antiviral therapy is associated with achievement of statistical cure of patients with hepatocellular carcinoma (HCC) undergoing liver resection (LR) remains unknown. We aimed to clarify this issue.

Methods

We enrolled 1004 patients with HCC who underwent LR. We evaluated overall survival (OS) as the primary survival measure for estimating cure fractions through a mixture model.

Results

The probability of resection enabling patients with HCC to achieve the same life expectancy as that of the general population was 48.6%. The multivariable cure model revealed that age ≤ 65 years, 7th edition pathological American Joint Committee on Cancer (AJCC) stage 1, no cirrhosis, receipt of antiviral therapy, and a Model for End-Stage Liver Disease (MELD) score of ≤ 9 were predictors of cure after LR.

Conclusions

About five in 10 patients could be considered cured after LR for HCC. In addition to tumor- and liver-related variables, receipt of antiviral therapy was associated with achievement of statistical cure. We highlight the importance of antiviral therapy for maximizing outcomes of resection for HCC.