<p>This study investigates the behavior of self-drilling screwed connections under shear effects through experimental and numerical methods, proposing new design equations. In the experimental study, 32 connections were tested to evaluate the effect of screw diameter, number, spacing, arrangement, and plate thickness on load-bearing capacity and failure modes. Results revealed that the vertical distance between the screw and the corner was the most critical factor for net section failure, regardless of screw diameter. For shear failure, plate thickness and screw diameter were key determinants. Increasing screw diameter and plate thickness enhanced the connections’ load-bearing capacity. The numerical study involved 86 finite element models to validate experimental findings and assess additional parameters, such as screw arrangements and t₂/t₁ ratios. The numerical results aligned with the experiments, confirming that higher t₂/t₁ ratios improved load-bearing capacity. Models with double screws in a row arrangement carried more load than those with screws in separate columns. Comparisons with the AISI S100 standard approach highlighted discrepancies, prompting the development of a new design equation. This equation demonstrated better consistency with experimental and numerical data, providing a more reliable assessment of connection behavior under shear effects.</p>