<p>The aim of the present study is to address the limitations of conventional voice former-based hollow-core systems, especially those arising from the use of void formers, including the risk of toxic gas release in the event of a fire and insufficient energy efficiency, by replacing such void formers with deck plates. Furthermore, a novel precast concrete (PC) hollow-core slab system, wherein openings were formed in the rib cross-sections of PC members, was proposed, and its structural performance was experimentally evaluated. The number of openings (section loss ratio) and the shear reinforcement arrangement (loop and lattice types) were selected as the primary variables. Two-point bending tests were conducted on a total of four specimens for each case. The experimental results demonstrated that the strength and ductility of the lattice-type shear reinforcement decreased with an increasing number of openings, due to the loss of cross-sectional area. In contrast, the loop-type shear reinforcement exhibited improved ductility and maximum load as the number of openings increased. According to the strain analysis results, the lattice-type specimen exhibited a uniform strain distribution in both concrete and reinforcement, confirming its superior distribution of shear stress. The PC hollow-core slab system proposed in this study is expected to combine excellent structural stability with enhanced energy dissipation performance. A future study will focus on verifying the applicability of the developed system to buildings with thermal energy storage designed to utilize excess energy from wind flow in four directions.</p>