<p>In this study, efficient finite element modeling concept and application for a sub-assembly structure are presented to assess the progressive collapse resistance performance of a whole structure considering the three-dimensional effect of the slabs, the continuity of the adjacent spans, and the stress redistribution through the alternative path of the upper floors. Three modeling levels were considered based on the degree of lateral behavior simulation by considering the flexural rigidity of columns and girders outside the influenced range. Furthermore, the modeling methods for a sub-assembly structure were evaluated by comparing the load-displacement relationship, girder stress, and plastic hinge locations with those obtained from the simulation of the whole structure model. The results indicate that the sub-assembly structure modeling can significantly reduce time in modeling and analyzing large structures and yield reliable results for appraising progressive collapse resistance performance.</p>