<p>To enhance the seismic performance of super high-rise buildings, this paper proposes a nonlinear seismic response analysis of super high-rise frame core tube structures based on the Bouc–Wen model. Using the Bouc–Wen model as the material model, the stiffness ratio, hysteretic shape parameters, strength degradation and stiffness degradation parameters are solved, the parameters of the Bouc–Wen model are identified through genetic algorithm, and the super high-rise frame core tube structure is designed accordingly. Concrete material model, steel bar, section steel material model and beam-column node element model, and finally the frame-core tube structure model is constructed. Eight seismic waves were selected to simulate the earthquake situation to test the nonlinear seismic response of the frame core tube structure of the super high-rise building. The experimental results show that the super high-rise frame core tube structure can reduce the floor shear, the displacement angle between floors and the floor displacement are small, and the top layer displacement and acceleration of the frame core tube structure are reduced. The super high-rise frame core tube structure based on the Bouc–Wen model has better damping efficiency under large earthquakes than under moderate earthquakes, and exhibits excellent seismic performance to protect more structural members from damage under large earthquakes.</p>