Objective <p>Ototoxic hearing loss can be divided into that caused by medication, and that caused by industrial chemicals. I use gene ontology analysis to focus on the functional predictions, and summarize the cochlear and vestibular distributions of functional genes.</p> Methods <p>To predict and consider ototoxic changes related to gene expression, I list the ototoxic chemicals and analyze their gene expression.</p> Results <p>These include a literature to develop a list of ototoxic chemicals and related research trends; examination of the toxicogenomic changes of ototoxic chemicals and organization of an EXCEL file, etc.; examination of the metabolic pathways related to toxicogenomic changes and epigenetics related to hearing, and preparation of a plan of preventive measures for ototoxicity caused by chemical exposure.</p> Conclusion <p>Wearing of protective gear and regular health monitoring to reduce exposure are essential to prevent hearing damage caused by ototoxic chemicals. This will contribute to creating a safe environment in the workplace by having companies and workers practice preventive measures together.</p> Purpose of the review <p>I aimed to examine the toxicogenomic changes of ototoxic chemicals, and based on the results, to contribute to the establishment of preventive measures against the ototoxicity of chemicals.</p> Recent findings <p>A literature review identifies a list of ototoxic chemicals and related research trends. Toxicogenomic changes in ototoxic chemicals are examined, and compiled in EXCEL. Metabolic pathways related to toxic genome changes are examined, and epigenetics related to hearing loss are described.</p>