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Background <p>Sodium <i>p</i>-perfluorous nonenoxybenzene sulfonate (OBS) and perfluorooctanoic acid (PFOA) are commonly used worldwide. However, few studies have focused on the serum metabolomic analysis and the differences between OBS and PFOA exposure.</p> Objective <p>We aimed to elucidate the serum metabolomic profiles alterations in mice resulting from exposure to PFOA and OBS via serum gas chromatography-time-of-flight mass spectrometry (GC-TOF/MS) analysis.</p> Results <p>Upon exposure to PFOA and OBS, the mice presented a significant decrease in body weight (<i>P</i> &lt; 0.01) and serum total superoxide dismutase concentration (<i>P</i> &lt; 0.05), as well as an increase in liver weight (<i>P</i> &lt; 0.01) and elevated serum alanine aminotransferase levels (<i>P</i> &lt; 0.01). Exposure to both PFOA and OBS induced hepatic tissue damage in mice. Serum metabolite analysis revealed that PFOA exposure predominantly disrupted the metabolism of amino acids, such as <span>l</span>-valine and <span>l</span>-carnitine, whereas OBS exposure primarily affected retinol metabolism, including 9-cis-retinoic acid and all-trans-5,6-epoxy retinoic acid.</p> Conclusions <p>In conclusion, this study provides a theoretical foundation for the risks associated with prolonged exposure to PFOA and OBS in mice.</p>

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Serum metabolomic analysis in mice exposed to perfluorooctanoic acid and sodium p-perfluorous nonenoxybenzene sulfonate

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Yuting Xu,
  • Ruochen Ren,
  • Minjie Yu,
  • Wentong Zheng,
  • Yang Wen,
  • Zhen Wang,
  • Hongbo Zeng

摘要

Background

Sodium p-perfluorous nonenoxybenzene sulfonate (OBS) and perfluorooctanoic acid (PFOA) are commonly used worldwide. However, few studies have focused on the serum metabolomic analysis and the differences between OBS and PFOA exposure.

Objective

We aimed to elucidate the serum metabolomic profiles alterations in mice resulting from exposure to PFOA and OBS via serum gas chromatography-time-of-flight mass spectrometry (GC-TOF/MS) analysis.

Results

Upon exposure to PFOA and OBS, the mice presented a significant decrease in body weight (P < 0.01) and serum total superoxide dismutase concentration (P < 0.05), as well as an increase in liver weight (P < 0.01) and elevated serum alanine aminotransferase levels (P < 0.01). Exposure to both PFOA and OBS induced hepatic tissue damage in mice. Serum metabolite analysis revealed that PFOA exposure predominantly disrupted the metabolism of amino acids, such as l-valine and l-carnitine, whereas OBS exposure primarily affected retinol metabolism, including 9-cis-retinoic acid and all-trans-5,6-epoxy retinoic acid.

Conclusions

In conclusion, this study provides a theoretical foundation for the risks associated with prolonged exposure to PFOA and OBS in mice.