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Background <p>Human diseases may be a result of disruptions in homeostasis. Our previous studies suggest that, among several kinds of homeostasis, immune and redox homeostasis may be the most essential axis. Despite our cumulative reports to support the immunoredox model, still there has been neither theory nor review to explain the immunoredox model.</p> Objectives <p>To address this, this review introduces the limitations of the existent immune recognition model, and enlighten the necessity, construction, and rationale of the new immunoredox model, as well as its application and implications for human disease and toxicology. Specifically, for the application to disease, comparison between immunoscore and immunoredox profiling was discussed as the first note.</p> Conclusions <p>Model-based Immunoredox profiling offers a comprehensive quantitative and qualitative analysis of immunokine and redox molecule interactions, focusing on the balance between immune and redox systems. This method facilitates the detection of subtle imbalances and abnormalities, enhancing the understanding, prediction, and evaluation of health issues arising from environmental toxins and inherent diseases. As a significant advancement in immunotoxicology, it provides critical insights into immune-toxicity interactions, supporting risk assessment and health mitigation strategies.</p>

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Immunoredox model for interpretation and prediction of human diseases

  • 期刊论文

  • 发表日期：

    2025年2月13日

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  • Justin Namuk Kim,
  • Hyungdon Lee,
  • Sofian Abdul-Nasir,
  • Yoon-Sun Park,
  • Soo-Ki Kim

摘要

Background

Human diseases may be a result of disruptions in homeostasis. Our previous studies suggest that, among several kinds of homeostasis, immune and redox homeostasis may be the most essential axis. Despite our cumulative reports to support the immunoredox model, still there has been neither theory nor review to explain the immunoredox model.

Objectives

To address this, this review introduces the limitations of the existent immune recognition model, and enlighten the necessity, construction, and rationale of the new immunoredox model, as well as its application and implications for human disease and toxicology. Specifically, for the application to disease, comparison between immunoscore and immunoredox profiling was discussed as the first note.

Conclusions

Model-based Immunoredox profiling offers a comprehensive quantitative and qualitative analysis of immunokine and redox molecule interactions, focusing on the balance between immune and redox systems. This method facilitates the detection of subtle imbalances and abnormalities, enhancing the understanding, prediction, and evaluation of health issues arising from environmental toxins and inherent diseases. As a significant advancement in immunotoxicology, it provides critical insights into immune-toxicity interactions, supporting risk assessment and health mitigation strategies.