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<p>The leptin (LEP) gene plays a key role in fat metabolism, energy balance, and reproductive performance in pigs. This study investigated two polymorphisms, g.3156C &gt; T and g.4124A &gt; G, in crossbred and indigenous Niang Megha pigs and evaluated their association with reproductive traits, including litter size at birth (LB), litter size at weaning (LW), average birth weight (ABW), and average weaning weight (AWW). Genotyping was performed using PCR–RFLP. The g.3156C &gt; T SNP was polymorphic in both populations, with C and T allele frequencies of 0.385 and 0.615 in crossbred pigs, and 0.808 and 0.192 in Niang Megha pigs. In crossbreds, the C allele tended to be associated with reproductive traits, with sows carrying the CC genotype showing numerically higher ABW and AWW in later parities, although these differences were not statistically significant (<i>P</i> &gt; 0.05). No significant associations were observed in the Niang Megha population. The g.4124A &gt; G SNP was polymorphic only in crossbred pigs (A: 0.546, G: 0.454), whereas the Niang Megha population was monomorphic with only the GG genotype. In crossbreds, sows with the AA genotype exhibited higher weaning weight; however, the differences were not statistically significant (<i>P</i> &gt; 0.05). These findings indicate that LEP gene polymorphisms may influence reproductive traits in a parity-dependent manner, particularly in crossbred pigs. However, the observed effects were generally non-significant and require further validation in larger and more diverse populations before their application in breeding programs. This article aligns with the United Nations Sustainable Development Goal (SDG 2: Zero Hunger) by supporting sustainable livestock production and genetic improvement strategies aimed at enhancing reproductive efficiency, productivity, and food security.</p>

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Association of two LEP gene SNPs with reproductive performance in pigs: Potential markers for genetic selection

  • 期刊论文

  • 发表日期：

    2026年7月15日

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  • Rakesh Kumar,
  • Kadirvel Govindasamy,
  • Gautam Khargharia,
  • Erica Lawai Lyngdoh,
  • Meena Das,
  • Mahak Singh,
  • Nakambam Manoranjan Singh,
  • Lisham Anandakumar Singh

摘要

The leptin (LEP) gene plays a key role in fat metabolism, energy balance, and reproductive performance in pigs. This study investigated two polymorphisms, g.3156C > T and g.4124A > G, in crossbred and indigenous Niang Megha pigs and evaluated their association with reproductive traits, including litter size at birth (LB), litter size at weaning (LW), average birth weight (ABW), and average weaning weight (AWW). Genotyping was performed using PCR–RFLP. The g.3156C > T SNP was polymorphic in both populations, with C and T allele frequencies of 0.385 and 0.615 in crossbred pigs, and 0.808 and 0.192 in Niang Megha pigs. In crossbreds, the C allele tended to be associated with reproductive traits, with sows carrying the CC genotype showing numerically higher ABW and AWW in later parities, although these differences were not statistically significant (P > 0.05). No significant associations were observed in the Niang Megha population. The g.4124A > G SNP was polymorphic only in crossbred pigs (A: 0.546, G: 0.454), whereas the Niang Megha population was monomorphic with only the GG genotype. In crossbreds, sows with the AA genotype exhibited higher weaning weight; however, the differences were not statistically significant (P > 0.05). These findings indicate that LEP gene polymorphisms may influence reproductive traits in a parity-dependent manner, particularly in crossbred pigs. However, the observed effects were generally non-significant and require further validation in larger and more diverse populations before their application in breeding programs. This article aligns with the United Nations Sustainable Development Goal (SDG 2: Zero Hunger) by supporting sustainable livestock production and genetic improvement strategies aimed at enhancing reproductive efficiency, productivity, and food security.