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<p>The state of Haryana in India is known for its archaeological sites related to the Indus Valley Civilisation and is a region of high ethnic and linguistic diversity. However, insufficient forensic DNA data is available from this region. The present study addresses this gap by genotyping 253 individuals using the Microreader™ 28 A ID system. The results show that all 24 loci were highly polymorphic, with a combined discrimination power and exclusion power of 1. Most loci demonstrated high informativeness, confirming their forensic efficacy in the studied population. Population genetic analyses revealed significant structure—the general Haryana population occupied an intermediate genetic position, while subgroup analyses showed distinct ancestries, reflecting complex social substructure of the region. Our findings highlight the necessity of population-specific validation of STR marker efficacy, especially for endogamous Indian populations. In summary, this study affirms that the Microreader™ 28 A ID system is a powerful and reliable tool for forensic DNA profiling and paternity testing in this Indian population. Furthermore, this comprehensive dataset provides valuable insights into the genetic history and demographic dynamics of North India. This article aligns with SDG 15 (Life on Land) of the UN Agenda for Sustainable Development.</p>

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Forensic efficacy evaluation of the Microreader™ 28 A ID System in Indian subpopulation

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Shivkant Sharma,
  • Vivek Sahajpal,
  • Jaison Jeevan Sequeira,
  • Abhishek Singh,
  • Mukesh Kumar Thakar

摘要

The state of Haryana in India is known for its archaeological sites related to the Indus Valley Civilisation and is a region of high ethnic and linguistic diversity. However, insufficient forensic DNA data is available from this region. The present study addresses this gap by genotyping 253 individuals using the Microreader™ 28 A ID system. The results show that all 24 loci were highly polymorphic, with a combined discrimination power and exclusion power of 1. Most loci demonstrated high informativeness, confirming their forensic efficacy in the studied population. Population genetic analyses revealed significant structure—the general Haryana population occupied an intermediate genetic position, while subgroup analyses showed distinct ancestries, reflecting complex social substructure of the region. Our findings highlight the necessity of population-specific validation of STR marker efficacy, especially for endogamous Indian populations. In summary, this study affirms that the Microreader™ 28 A ID system is a powerful and reliable tool for forensic DNA profiling and paternity testing in this Indian population. Furthermore, this comprehensive dataset provides valuable insights into the genetic history and demographic dynamics of North India. This article aligns with SDG 15 (Life on Land) of the UN Agenda for Sustainable Development.