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<p>The increasing prevalence of micronutrient malnutrition and non-communicable diseases has intensified the demand for nutritious diets with increased bioavailability. The study presents a strategy to promote the consumption of whole-grain brown rice through the reduction of the anti-nutritional factor, phytic acid (PA), in rice grains. Using the next generation sequencing based rapid mapping approach QTLseq, we have identified four significant QTLs in chromosomes 1, 5 (2) and 7 associated with low phytic acid&#xa0;(LPA) in the donor Shah Pasand. Integrated analysis of significant SNPs, allele divergence patterns, and SNPEff-based functional annotation enabled the identification of a coherent set of 10 putative candidate genes associated with inositol phosphate metabolism and PA transport. Notable among them are the genes coding phosphoglycerate kinase, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding protein, and the ABC transporters. These QTLs, genes, and their corresponding allelic variants hold immense potential in marker-assisted breeding programs aimed at developing nutrient-dense rice varieties with enhanced bioavailability. This article aligns with SDG 2 (Zero Hunger) of the UN Agenda for Sustainable Development.</p>

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Novel QTLs governing low phytic acid (LPA) in rice revealed through QTLseq approach

  • 期刊论文

  • 发表日期：

    2026年4月23日

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  • Haritha Bollinedi,
  • Meena Adikari,
  • Gopala Krishnan Subbaiyan,
  • Prolay Kumar Bhowmick,
  • Nagarajan Mariappan,
  • Vinod Kunnummal Kurungara,
  • Ranjith Kumar Ellur,
  • Karishma Bisht,
  • Ashok Kumar Singh

摘要

The increasing prevalence of micronutrient malnutrition and non-communicable diseases has intensified the demand for nutritious diets with increased bioavailability. The study presents a strategy to promote the consumption of whole-grain brown rice through the reduction of the anti-nutritional factor, phytic acid (PA), in rice grains. Using the next generation sequencing based rapid mapping approach QTLseq, we have identified four significant QTLs in chromosomes 1, 5 (2) and 7 associated with low phytic acid (LPA) in the donor Shah Pasand. Integrated analysis of significant SNPs, allele divergence patterns, and SNPEff-based functional annotation enabled the identification of a coherent set of 10 putative candidate genes associated with inositol phosphate metabolism and PA transport. Notable among them are the genes coding phosphoglycerate kinase, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding protein, and the ABC transporters. These QTLs, genes, and their corresponding allelic variants hold immense potential in marker-assisted breeding programs aimed at developing nutrient-dense rice varieties with enhanced bioavailability. This article aligns with SDG 2 (Zero Hunger) of the UN Agenda for Sustainable Development.