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<p>Linear type traits are important for animal breeders for making selection decision in dairy cattle because of their significant influence on production and close association with mastitis. The objective of this study was to identify and evaluate the effects of SNPs in the bovine candidate genes, Interleukin 22 (IL22) and Complement component 4 (C4A), with milk production as well as linear type traits in Karan Fries (<i>Bos taurus</i> × <i>Bos indicus</i>) and Sahiwal (<i>Bos indicus</i>) cows. Four SNPs i.e. rs482793551, rs458036541, rs482793664 and rs455271937 in IL22 gene and two SNPs i.e. rs137485678 and rs132741478 in C4A gene were identified. Interestingly, SNPs rs458036541, rs482793551, and rs455271937 were detected exclusively in Sahiwal cattle, whereas SNP rs482793664 and rs132741478 were uniquely observed in Karan Fries cattle, indicating breed-specific genetic variations. The AA genotype of rs482793664 was found to have deeper central ligament, thicker teats and larger teat diameter, shorter distance from rear teat end to floor and shorter distance from fore teat end to floor in Karan Fries cattle. In Sahiwal cattle, SNPs rs458036541, rs482793551 and rs455271937 were found to be associated with fore udder attachment. The CC genotype of SNP rs455271937 had deeper udder and longer fore teats in Sahiwal. The panel of identified and verified SNPs from this study for both indigenous and crossbred cattle will be useful for&#xa0;marker assisted selection in dairy breeding programs in these breeds.</p>

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Association of IL22 and C4A gene with production and udder conformation traits in Sahiwal (Bos indicus) and Karan Fries (Bos taurus x Bos indicus) cattle

  • 期刊论文

  • 发表日期：

    2025年10月20日

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  • Sushil Kumar,
  • Anshuman Kumar,
  • Nisha Sharma,
  • Revanasiddu Deginal,
  • Archana Verma,
  • Ishwar Dayal Gupta

摘要

Linear type traits are important for animal breeders for making selection decision in dairy cattle because of their significant influence on production and close association with mastitis. The objective of this study was to identify and evaluate the effects of SNPs in the bovine candidate genes, Interleukin 22 (IL22) and Complement component 4 (C4A), with milk production as well as linear type traits in Karan Fries (Bos taurus × Bos indicus) and Sahiwal (Bos indicus) cows. Four SNPs i.e. rs482793551, rs458036541, rs482793664 and rs455271937 in IL22 gene and two SNPs i.e. rs137485678 and rs132741478 in C4A gene were identified. Interestingly, SNPs rs458036541, rs482793551, and rs455271937 were detected exclusively in Sahiwal cattle, whereas SNP rs482793664 and rs132741478 were uniquely observed in Karan Fries cattle, indicating breed-specific genetic variations. The AA genotype of rs482793664 was found to have deeper central ligament, thicker teats and larger teat diameter, shorter distance from rear teat end to floor and shorter distance from fore teat end to floor in Karan Fries cattle. In Sahiwal cattle, SNPs rs458036541, rs482793551 and rs455271937 were found to be associated with fore udder attachment. The CC genotype of SNP rs455271937 had deeper udder and longer fore teats in Sahiwal. The panel of identified and verified SNPs from this study for both indigenous and crossbred cattle will be useful for marker assisted selection in dairy breeding programs in these breeds.