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<p>Cardiomyopathy is a major risk factor for cardiac dysfunction, which is caused by a complicated interaction between environmental and hereditary variables. Changes in the MYH7 gene help to understand how heart muscle cells work and how these changes can lead to heart problems. This study examines the relationship between cardiac dysfunction in the Jammu population and the <i>MYH7</i> rs397516208 (G &gt; A) variant. The study comprised 500 healthy controls and 250 patients with cardiomyopathy. PCR–RFLP was used to genotype the <i>MYH7</i> variant. Detailed statistical analyses revealed that patients had a considerably higher prevalence of the MYH7 (rs397516208) AA genotype than controls (<i>p</i> &lt; 0.001), indicating a strong genetic link with heart dysfunction. Cholesterol is a significant contributor to the progression of heart disease, and a statistically significant association (<i>p</i> &lt; 0.05) was found between the disease group and cholesterol levels. Also, alcohol consumption increases the risk of cardiomyopathy by twofold in people with AA variants (OR = 2.4 [CI = 1.075−22.91] <i>p</i> &lt; 0.04). In conclusion, the <i>MYH7</i> (rs397516208) variant is genetically linked to cardiac dysfunction and may contribute to the pathophysiology of heart failure and related cardiac disorders.</p> Graphical abstract <p></p>

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Impact of MYH7 gene polymorphism and lifestyle factors on cardiomyopathy susceptibility in Jammu: a case–control analysis

  • 期刊论文

  • 发表日期：

    2025年10月9日

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  • Shikha Bharti,
  • Shashank Garg,
  • Rakesh Kumar Panjaliya,
  • Dharminder Kumar,
  • Mohd. Younis,
  • Najitha Banu,
  • Parvinder Kumar

摘要

Cardiomyopathy is a major risk factor for cardiac dysfunction, which is caused by a complicated interaction between environmental and hereditary variables. Changes in the MYH7 gene help to understand how heart muscle cells work and how these changes can lead to heart problems. This study examines the relationship between cardiac dysfunction in the Jammu population and the MYH7 rs397516208 (G > A) variant. The study comprised 500 healthy controls and 250 patients with cardiomyopathy. PCR–RFLP was used to genotype the MYH7 variant. Detailed statistical analyses revealed that patients had a considerably higher prevalence of the MYH7 (rs397516208) AA genotype than controls (p < 0.001), indicating a strong genetic link with heart dysfunction. Cholesterol is a significant contributor to the progression of heart disease, and a statistically significant association (p < 0.05) was found between the disease group and cholesterol levels. Also, alcohol consumption increases the risk of cardiomyopathy by twofold in people with AA variants (OR = 2.4 [CI = 1.075−22.91] p < 0.04). In conclusion, the MYH7 (rs397516208) variant is genetically linked to cardiac dysfunction and may contribute to the pathophysiology of heart failure and related cardiac disorders.

Graphical abstract